Increased body fat mass and androgen metabolism - A twin study in healthy young women

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Vihma , V , Heinonen , S , Naukkarinen , J , Kaprio , J , Rissanen , A , Turpeinen , U , Hämäläinen , E , Hakkarainen , A , Lundbom , J , Lundbom , N , Mikkola , T S , Tikkanen , M J & Pietiläinen , K H 2018 , ' Increased body fat mass and androgen metabolism - A twin study in healthy young women ' , Steroids , vol. 140 , pp. 24-31 . https://doi.org/10.1016/j.steroids.2018.08.006

Title: Increased body fat mass and androgen metabolism - A twin study in healthy young women
Author: Vihma, Veera; Heinonen, Sini; Naukkarinen, Jussi; Kaprio, Jaakko; Rissanen, Aila; Turpeinen, Ursula; Hämäläinen, Esa; Hakkarainen, Antti; Lundbom, Jesper; Lundbom, Nina; Mikkola, Tomi S.; Tikkanen, Matti J.; Pietiläinen, Kirsi H.
Contributor: University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Diabetes and Obesity Research Program
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Research Programs Unit
University of Helsinki, Clinicum
University of Helsinki, Medicum
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
Date: 2018-12
Language: eng
Number of pages: 8
Belongs to series: Steroids
ISSN: 0039-128X
URI: http://hdl.handle.net/10138/289231
Abstract: Objective: Obesity may alter serum steroid concentrations and metabolism. We investigated this in healthy young women with increased body fat and their leaner co-twin sisters. Design: Age and genetic background both strongly influence serum steroid levels and body composition. This is a cross-sectional study of 13 female monozygotic twin pairs (age, 23-36 years), ten of which were discordant for body mass index (median difference in body weight between the co-twins, 19 kg). Methods: We determined body composition by dual energy X-ray absorptiometry and magnetic resonance imaging, serum androgens by liquid chromatography-tandem mass spectrometry, and mRNA expression of genes in subcutaneous adipose tissue and adipocytes. Results: The heavier women had lower serum dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) (P <0.05 for all) compared to their leaner co-twins with no differences in serum testosterone or androstenedione levels. Serum DHEA correlated inversely with %body fat (r = -0.905, P = 0.002), and DHT positively with SHBG (r = 0.842, P = 0.002). In adipose tissue or adipocytes, expressions of STS (steroid sulfatase) and androgen-related genes were significantly higher in the heavier compared to the leaner co-twin, and within pairs, correlated positively with adiposity but were not related to serum androgen levels. None of the serum androgen or SHBG levels correlated with indices of insulin resistance. Conclusions: Serum DHEA levels were best predicted by %body fat, and serum DHT by SHBG. These or other serum androgen concentrations did not reflect differences in androgen-related genes in adipose tissue. General or intra-abdominal adiposity were not associated with increased androgenicity in young women.
Subject: Adipose tissue
obesity
steroid hormone
dehydroepiandrosterone
steroid sulfatase
monozygotic twins
DEHYDROEPIANDROSTERONE CIRCULATING LEVELS
ADIPOSE-TISSUE
SEX-HORMONES
OBESITY
SERUM
TESTOSTERONE
WEIGHT
INTERRELATIONSHIPS
ACCUMULATION
STEROIDS
3121 General medicine, internal medicine and other clinical medicine
1182 Biochemistry, cell and molecular biology
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