Increased body fat mass and androgen metabolism - A twin study in healthy young women

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Vihma , V , Heinonen , S , Naukkarinen , J , Kaprio , J , Rissanen , A , Turpeinen , U , Hämäläinen , E , Hakkarainen , A , Lundbom , J , Lundbom , N , Mikkola , T S , Tikkanen , M J & Pietiläinen , K H 2018 , ' Increased body fat mass and androgen metabolism - A twin study in healthy young women ' , Steroids , vol. 140 , pp. 24-31 .

Title: Increased body fat mass and androgen metabolism - A twin study in healthy young women
Author: Vihma, Veera; Heinonen, Sini; Naukkarinen, Jussi; Kaprio, Jaakko; Rissanen, Aila; Turpeinen, Ursula; Hämäläinen, Esa; Hakkarainen, Antti; Lundbom, Jesper; Lundbom, Nina; Mikkola, Tomi S.; Tikkanen, Matti J.; Pietiläinen, Kirsi H.
Contributor organization: HUS Heart and Lung Center
Department of Medicine
Diabetes and Obesity Research Program
Research Programs Unit
University of Helsinki
Institute for Molecular Medicine Finland
Department of Public Health
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Department of Obstetrics and Gynecology
HUS Gynecology and Obstetrics
Endokrinologian yksikkö
HUS Abdominal Center
HUS Internal Medicine and Rehabilitation
Genetic Epidemiology
Date: 2018-12
Language: eng
Number of pages: 8
Belongs to series: Steroids
ISSN: 0039-128X
Abstract: Objective: Obesity may alter serum steroid concentrations and metabolism. We investigated this in healthy young women with increased body fat and their leaner co-twin sisters. Design: Age and genetic background both strongly influence serum steroid levels and body composition. This is a cross-sectional study of 13 female monozygotic twin pairs (age, 23-36 years), ten of which were discordant for body mass index (median difference in body weight between the co-twins, 19 kg). Methods: We determined body composition by dual energy X-ray absorptiometry and magnetic resonance imaging, serum androgens by liquid chromatography-tandem mass spectrometry, and mRNA expression of genes in subcutaneous adipose tissue and adipocytes. Results: The heavier women had lower serum dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) (P <0.05 for all) compared to their leaner co-twins with no differences in serum testosterone or androstenedione levels. Serum DHEA correlated inversely with %body fat (r = -0.905, P = 0.002), and DHT positively with SHBG (r = 0.842, P = 0.002). In adipose tissue or adipocytes, expressions of STS (steroid sulfatase) and androgen-related genes were significantly higher in the heavier compared to the leaner co-twin, and within pairs, correlated positively with adiposity but were not related to serum androgen levels. None of the serum androgen or SHBG levels correlated with indices of insulin resistance. Conclusions: Serum DHEA levels were best predicted by %body fat, and serum DHT by SHBG. These or other serum androgen concentrations did not reflect differences in androgen-related genes in adipose tissue. General or intra-abdominal adiposity were not associated with increased androgenicity in young women.
Subject: Adipose tissue
steroid hormone
steroid sulfatase
monozygotic twins
3121 General medicine, internal medicine and other clinical medicine
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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