Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017

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dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Troeger, Christopher E.
dc.contributor.author Blacker, Brigette F.
dc.contributor.author Khalil, Ibrahim A.
dc.contributor.author Zimsen, Stephanie R. M.
dc.contributor.author Albertson, Samuel B.
dc.contributor.author Abate, Degu
dc.contributor.author Abdela, Jemal
dc.contributor.author Adhikari, Tara Ballav
dc.contributor.author Aghayan, Sargis Aghasi
dc.contributor.author Agrawal, Sutapa
dc.contributor.author Ahmadi, Alireza
dc.contributor.author Aichour, Amani Nidhal
dc.contributor.author Aichour, Ibtihel
dc.contributor.author Aichour, Miloud Taki Eddine
dc.contributor.author Al-Eyadhy, Ayman
dc.contributor.author Al-Raddadi, Rajaa M.
dc.contributor.author Alahdab, Fares
dc.contributor.author Alene, Kefyalew Addis
dc.contributor.author Aljunid, Syed Mohamed
dc.contributor.author Alvis-Guzman, Nelson
dc.contributor.author Anber, Nahla Hamed
dc.contributor.author Anjomshoa, Mina
dc.contributor.author Antonio, Carl Abelardo T.
dc.contributor.author Aremu, Olatunde
dc.contributor.author Atalay, Hagos Tasew
dc.contributor.author Atique, Suleman
dc.contributor.author Attia, Engi F.
dc.contributor.author Avokpaho, Euripide F. G. A.
dc.contributor.author Awasthi, Ashish
dc.contributor.author Babazadeh, Arefeh
dc.contributor.author Badali, Hamid
dc.contributor.author Badawi, Alaa
dc.contributor.author Banoub, Joseph Adel Mattar
dc.contributor.author Barac, Aleksandra
dc.contributor.author Bassat, Quique
dc.contributor.author Bedi, Neeraj
dc.contributor.author Belachew, Abate Bekele
dc.contributor.author Bennett, Derrick A.
dc.contributor.author Bhattacharyya, Krittika
dc.contributor.author Bhutta, Zulfiqar A.
dc.contributor.author Bijani, Ali
dc.contributor.author Carvalho, Felix
dc.contributor.author Castaneda-Orjuela, Carlos A.
dc.contributor.author Christopher, Devasahayam J.
dc.contributor.author Dandona, Lalit
dc.contributor.author Dandona, Rakhi
dc.contributor.author Dang, Anh Kim
dc.contributor.author Daryani, Ahmad
dc.contributor.author Degefa, Meaza Girma
dc.contributor.author Meretoja, Tuomo J.
dc.date.accessioned 2019-01-11T07:20:01Z
dc.date.available 2019-01-11T07:20:01Z
dc.date.issued 2019-01
dc.identifier.citation GBD 2017 Influenza Collaborators 2019 , ' Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 : an analysis for the Global Burden of Disease Study 2017 ' The Lancet respiratory medicine , vol. 7 , no. 1 , pp. 69-89 . https://doi.org/10.1016/S2213-2600(18)30496-X en
dc.identifier.issn 2213-2600
dc.identifier.other PURE: 121047298
dc.identifier.other PURE UUID: 82d36b6f-8397-438d-b7a8-2b09043d3b6a
dc.identifier.other WOS: 000454152600018
dc.identifier.other Scopus: 85058918960
dc.identifier.other ORCID: /0000-0002-2691-0710/work/52696649
dc.identifier.uri http://hdl.handle.net/10138/290308
dc.description.abstract Background Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000-200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16.4 deaths per 100 000 [95% UI 11.6-21.9]), and the highest rate among all ages was in eastern Europe (5.2 per 100 000 population [95% UI 3.5-7.2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000-22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000-259 851 000). We estimated that 11.5% (95% UI 10.0-12.9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000-73 864 000) episodes and 8 172 000 severe episodes (5 000 000-13 296 000). Interpretation This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Copyright (c) 2018 The Author(s). Published by Elsevier Ltd. en
dc.format.extent 21
dc.language.iso eng
dc.relation.ispartof The Lancet respiratory medicine
dc.rights en
dc.subject BACTERIAL en
dc.subject VACCINES en
dc.subject VACCINATION en
dc.subject PNEUMONIA en
dc.subject CHILDREN en
dc.subject AFRICA en
dc.subject 3121 Internal medicine en
dc.title Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017 en
dc.title an analysis for the Global Burden of Disease Study 2017 en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1016/S2213-2600(18)30496-X
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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