Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects

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Hemilä , H 2018 , ' Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects ' , Nutrition Reviews , vol. 76 , no. 9 , pp. 722-723 . https://doi.org/10.1093/nutrit/nuy038

Title: Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects
Author: Hemilä, Harri
Contributor organization: Harri Hemilä / Principal Investigator
Department of Public Health
Clinicum
University of Helsinki
Date: 2018-07-13
Language: eng
Number of pages: 2
Belongs to series: Nutrition Reviews
ISSN: 0029-6643
DOI: https://doi.org/10.1093/nutrit/nuy038
URI: http://hdl.handle.net/10138/292428
Abstract: To determine whether RRR α-tocopherol and all-racemic α-tocopherol might differ in their effects on health outcomes, Ranard and Erdman reviewed studies about these 2 forms of vitamin E. They concluded from the published studies that α-tocopherol might be of benefit only to some restricted populations. However, they did not fully discuss the evidence indicating that vitamin E supplementation may also be harmful for certain population groups. In our analyses of the Alpha-Tocopherol, Beta-Carotene (ATBC) Study of Finnish male smokers, we found that vitamin E (dl-α-tocopheryl acetate) had no effect in the majority of subjects. However, vitamin E was beneficial in certain categories of participants and harmful in others. ... At this stage, it does not seem feasible to search for a universal ratio of efficacy of RRR α-tocopherol to all-racemic α-tocopherol. Instead, it would seem more useful first to characterize definitively the population groups for which vitamin E supplementation may be beneficial and only thereafter compare the efficacy of different vitamin E forms in those groups
Subject: 3142 Public health care science, environmental and occupational health
Peer reviewed: No
Usage restriction: openAccess
Self-archived version: acceptedVersion


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