Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci

Show full item record



Permalink

http://hdl.handle.net/10138/293029

Citation

Gupta , R , van Dongen , J , Fu , Y , Abdellaoui , A , Tyndale , R F , Velagapudi , V , Boomsma , D I , Korhonen , T , Kaprio , J , Loukola , A & Ollikainen , M 2019 , ' Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci ' , Clinical epigenetics , vol. 11 , 1 . https://doi.org/10.1186/s13148-018-0606-9

Title: Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
Author: Gupta, Richa; van Dongen, Jenny; Fu, Yu; Abdellaoui, Abdel; Tyndale, Rachel F.; Velagapudi, Vidya; Boomsma, Dorret I.; Korhonen, Tellervo; Kaprio, Jaakko; Loukola, Anu; Ollikainen, Miina
Contributor organization: Institute for Molecular Medicine Finland
University Management
Department of Public Health
Clinicum
University of Helsinki
Department of Pathology
Medicum
HUS Abdominal Center
Epigenetics of Complex Diseases and Traits
Genetic Epidemiology
Date: 2019-01-05
Language: eng
Number of pages: 13
Belongs to series: Clinical epigenetics
ISSN: 1868-7083
DOI: https://doi.org/10.1186/s13148-018-0606-9
URI: http://hdl.handle.net/10138/293029
Abstract: BackgroundDNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N=310).ResultsDNA methylation at 50 CpG sites was associated (FDR
Subject: Epigenome-wide association study
Smoking
Cotinine
Genetic risk score
Nicotine metabolism
meQTL
Causal inference
Molecular mediation
NICOTINE METABOLITE RATIO
DIFFERENTIAL DNA METHYLATION
SELF-REPORTED SMOKING
CIGARETTE SMOKERS
BLOOD
BIOMARKER
PATHWAY
LUNG
CESSATION
ACCURACY
3122 Cancers
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
s13148_018_0606_9.pdf 1.431Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record