Roles for RAB24 in autophagy and disease

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http://hdl.handle.net/10138/297777

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Ylä-Anttila , P & Eskelinen , E-L 2018 , ' Roles for RAB24 in autophagy and disease ' , Small GTPases , vol. 9 , no. 1-2 , pp. 1-9 . https://doi.org/10.1080/21541248.2017.1317699

Title: Roles for RAB24 in autophagy and disease
Author: Ylä-Anttila, Päivi; Eskelinen, Eeva-Liisa
Contributor: University of Helsinki, Autophagy
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2018-03-04
Language: eng
Belongs to series: Small GTPases
ISSN: 2154-1248
URI: http://hdl.handle.net/10138/297777
Abstract: Autophagy is an evolutionarily conserved degradation pathway for cells to maintain homeostasis, produce energy, degrade misfolded proteins and damaged organelles, and fight against intracellular pathogens. The process of autophagy entails the isolation of cytoplasmic cargo into double membrane bound autophagosomes that undergo maturation by fusion with endosomes and lysosomes in order to obtain degradation capacity. RAB proteins regulate intracellular vesicle trafficking events including autophagy. RAB24 is an atypical RAB protein that is required for the clearance of late autophagic vacuoles under basal conditions. RAB24 has also been connected to several diseases including ataxia, cancer and tuberculosis. This review gives a short summary on autophagy and RAB proteins, and an overview on the current knowledge on the roles of RAB24 in autophagy and disease.
Subject: 1182 Biochemistry, cell and molecular biology
autophagy
RAB24
cancer
neurodegeneration
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