Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort

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Kormi , I , Nieminen , M T , Havulinna , A S , Zeller , T , Blankenberg , S , Tervahartiala , T , Sorsa , T , Salomaa , V & Pussinen , P J 2017 , ' Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort ' , European journal of preventive cardiology , vol. 24 , no. 11 , pp. 1136-1144 . https://doi.org/10.1177/2047487317706585

Title: Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort
Author: Kormi, Immi; Nieminen, Mikko T.; Havulinna, Aki S.; Zeller, Tanja; Blankenberg, Stefan; Tervahartiala, Taina; Sorsa, Timo; Salomaa, Veikko; Pussinen, Pirkko J.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Complex Disease Genetics
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-07
Language: eng
Number of pages: 9
Belongs to series: European journal of preventive cardiology
ISSN: 2047-4873
URI: http://hdl.handle.net/10138/297791
Abstract: Background Extracellular matrix degrading proteases and their regulators play an important role in atherogenesis and subsequent plaque rupture leading to acute cardiovascular manifestations. Design and methods In this prospective cohort study, we investigated the prognostic value of circulating matrix metalloproteinase-8, tissue inhibitor of matrix metalloproteinase-1 concentrations, the ratio of matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 and, for comparison, myeloperoxidase and C-reactive protein concentrations for incident cardiovascular disease endpoints. The population-based FINRISK97 cohort comprised 7928 persons without cardiovascular disease at baseline. The baseline survey included a clinical examination and blood sampling. During a 13-year follow-up the endpoints were ascertained through national healthcare registers. The associations of measured biomarkers with the endpoints, including cardiovascular disease event, coronary artery disease, acute myocardial infarction, stroke and all-cause death, were analysed using Cox regression models. Discrimination and reclassification models were used to evaluate the clinical implications of the biomarkers. Results Serum tissue inhibitor of matrix metalloproteinase-1 and C-reactive protein concentrations were associated significantly with increased risk for all studied endpoints. Additionally, matrix metalloproteinase-8 concentration was associated with the risk for a coronary artery disease event, myocardial infarction and death, and myeloperoxidase concentration with the risk for cardiovascular disease events, stroke and death. The only significant association for the matrix metalloproteinase-8/ tissue inhibitor of matrix metalloproteinase-1 ratio was observed with the risk for myocardial infarction. Adding tissue inhibitor of matrix metalloproteinase-1 to the established risk profile improved risk discrimination of myocardial infarction (p=0.039) and death (0.001). Both matrix metalloproteinase-8 (5.2%, p <0.001) and tissue inhibitor of matrix metalloproteinase-1 (12.9%, p <0.001) provided significant clinical net reclassification improvement for death. Conclusions Serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 can be considered as biomarkers of incident cardiovascular disease events and death.
Subject: Biomarker
cardiovascular outcomes
prediction
mortality
CORONARY-HEART-DISEASE
C-REACTIVE PROTEIN
HOSPITAL DISCHARGE REGISTER
ACUTE MYOCARDIAL-INFARCTION
LEFT-VENTRICULAR MEASURES
CAROTID PLAQUES
RISK-FACTORS
ATHEROSCLEROTIC PLAQUES
ARTERY-DISEASE
PLASMA-LEVELS
3121 General medicine, internal medicine and other clinical medicine
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