Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis : A proton decoupled P-31-MRS study

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Hakkarainen , A , Puustinen , L , Kivisaari , R , Boyd , S , Nieminen , U , Arkkila , P & Lundbom , N 2017 , ' Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis : A proton decoupled P-31-MRS study ' , European Journal of Radiology , vol. 90 , pp. 205-211 . https://doi.org/10.1016/j.ejrad.2017.01.008

Title: Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis : A proton decoupled P-31-MRS study
Author: Hakkarainen, Antti; Puustinen, Lauri; Kivisaari, Reetta; Boyd, Sonja; Nieminen, Urpo; Arkkila, Perttu; Lundbom, Nina
Contributor: University of Helsinki, Clinicum
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Gastroenterologian yksikkö
University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
Date: 2017-05
Language: eng
Number of pages: 7
Belongs to series: European Journal of Radiology
ISSN: 0720-048X
URI: http://hdl.handle.net/10138/297795
Abstract: Purpose: To study liver P-31 MRS, histology, transient elastography, and liver function tests in patients with virus C hepatitis (HCV) or autoimmune hepatitis (AIH) to test the hypothesis that P-31 MR metabolic profile of these diseases differ. Materials and methods: 25 patients with HCV (n = 12) or AIH (n = 13) underwent proton decoupled P-31 MRS spectroscopy performed on a 3.0 T MR imager. Intensities of phosphomonoesters (PME) of phosphoethanolamine (PE) and phosphocholine (PC), phosphodiesters (PDE) of glycerophosphoethanolamine( GPE) and glycerophosphocholine (GPC), and gamma, alpha and beta resonances of adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH) were determined. Liver stiffness was measured by transient elastography. Inflammation and fibrosis were staged according to METAVIR from biopsy samples. Activities of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT) and thromboplastin time (TT) were determined from serum samples. Results: PME had a stronger correlation with AST (z = 1.73, p = 0.04) and ALT (z = 1.77, p = 0.04) in HCV than in AIH patients. PME, PME/PDE, PE/GPE correlated positively and PDE negatively with inflammatory activity. PE, PC and PME correlated positively with liver function tests. Conclusion: P-31-MRS suggests a more serious liver damage in HCV than in AIH with similar histopathological findings. P-31-MRS is more sensitive in detecting inflammation than fibrosis in the liver. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Magnetic resonance spectroscopy
Liver, hepatitis C
Autoimmune hepatitis
Fibrosisa
MAGNETIC-RESONANCE-SPECTROSCOPY
MR SPECTROSCOPY
TRANSIENT ELASTOGRAPHY
ANTIVIRAL THERAPY
FIBROSIS
DISEASE
PERFORMANCE
CIRRHOSIS
BIOPSY
METAANALYSIS
3126 Surgery, anesthesiology, intensive care, radiology
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