Hakkarainen , A , Puustinen , L , Kivisaari , R , Boyd , S , Nieminen , U , Arkkila , P & Lundbom , N 2017 , ' Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis : A proton decoupled P-31-MRS study ' , European Journal of Radiology , vol. 90 , pp. 205-211 . https://doi.org/10.1016/j.ejrad.2017.01.008
Title: | Metabolic profile of liver damage in non-cirrhotic virus C and autoimmune hepatitis : A proton decoupled P-31-MRS study |
Author: | Hakkarainen, Antti; Puustinen, Lauri; Kivisaari, Reetta; Boyd, Sonja; Nieminen, Urpo; Arkkila, Perttu; Lundbom, Nina |
Contributor organization: | Clinicum University of Helsinki Department of Diagnostics and Therapeutics HUS Medical Imaging Center Gastroenterologian yksikkö Department of Medicine HUS Abdominal Center Medicum Department of Pathology Helsinki University Hospital Area |
Date: | 2017-05 |
Language: | eng |
Number of pages: | 7 |
Belongs to series: | European Journal of Radiology |
ISSN: | 0720-048X |
DOI: | https://doi.org/10.1016/j.ejrad.2017.01.008 |
URI: | http://hdl.handle.net/10138/297795 |
Abstract: | Purpose: To study liver P-31 MRS, histology, transient elastography, and liver function tests in patients with virus C hepatitis (HCV) or autoimmune hepatitis (AIH) to test the hypothesis that P-31 MR metabolic profile of these diseases differ. Materials and methods: 25 patients with HCV (n = 12) or AIH (n = 13) underwent proton decoupled P-31 MRS spectroscopy performed on a 3.0 T MR imager. Intensities of phosphomonoesters (PME) of phosphoethanolamine (PE) and phosphocholine (PC), phosphodiesters (PDE) of glycerophosphoethanolamine( GPE) and glycerophosphocholine (GPC), and gamma, alpha and beta resonances of adenosine triphosphate (ATP), and nicotinamide adenine dinucleotide phosphate (NADPH) were determined. Liver stiffness was measured by transient elastography. Inflammation and fibrosis were staged according to METAVIR from biopsy samples. Activities of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALT) and thromboplastin time (TT) were determined from serum samples. Results: PME had a stronger correlation with AST (z = 1.73, p = 0.04) and ALT (z = 1.77, p = 0.04) in HCV than in AIH patients. PME, PME/PDE, PE/GPE correlated positively and PDE negatively with inflammatory activity. PE, PC and PME correlated positively with liver function tests. Conclusion: P-31-MRS suggests a more serious liver damage in HCV than in AIH with similar histopathological findings. P-31-MRS is more sensitive in detecting inflammation than fibrosis in the liver. (C) 2017 Elsevier B.V. All rights reserved. |
Subject: |
Magnetic resonance spectroscopy
Liver, hepatitis C Autoimmune hepatitis Fibrosisa MAGNETIC-RESONANCE-SPECTROSCOPY MR SPECTROSCOPY TRANSIENT ELASTOGRAPHY ANTIVIRAL THERAPY FIBROSIS DISEASE PERFORMANCE CIRRHOSIS BIOPSY METAANALYSIS 3126 Surgery, anesthesiology, intensive care, radiology |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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