Risk factors and outcomes of tapering surgery for small intestinal dilatation in pediatric short bowel syndrome

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Hukkinen , M , Kivisaari , R , Koivusalo , A & Pakarinen , M P 2017 , ' Risk factors and outcomes of tapering surgery for small intestinal dilatation in pediatric short bowel syndrome ' , Journal of Pediatric Surgery , vol. 52 , no. 7 , pp. 1121-1127 . https://doi.org/10.1016/j.jpedsurg.2017.01.052

Title: Risk factors and outcomes of tapering surgery for small intestinal dilatation in pediatric short bowel syndrome
Author: Hukkinen, Maria; Kivisaari, Reetta; Koivusalo, Antti; Pakarinen, Mikko P.
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Lastenkirurgian yksikkö
University of Helsinki, Lastenkirurgian yksikkö
Date: 2017-07
Language: eng
Number of pages: 7
Belongs to series: Journal of Pediatric Surgery
ISSN: 0022-3468
URI: http://hdl.handle.net/10138/297801
Abstract: Background: In remains unclear why in some short bowel syndrome (SBS) patients, the remaining small bowel (SB) dilates excessively leading to requirement of tapering surgery. Methods: Among SBS children, we retrospectively analyzed risk factors for tapering surgery with logistic regression and compared the outcome of operated patients (n = 16) to those managed conservatively (n = 44) with Cox proportional hazards regression. Results: SBS was caused by necrotizing enterocolitis (NEC) (n = 31), SB atresia (SBA) (n = 13), midgut volvulus (n = 12), or gastroschisis (n = 4). Patients with spontaneous symptomatic SB dilatation unable to wean parenteral nutrition (PN) underwent tapering surgery at median age of 1.04 (interquartile range 0.70-3.27) years. Missing ICV was related to an 8-fold (p = 0.003) increased risk while SBA diagnosis was related to a 13-fold risk of tapering surgery (p <0.001). Increasing SB length and NEC diagnosis were protective of tapering (p = 0.027-0.004). Of operated patients, 75% reached enteral autonomy during follow-up and their postoperative adjusted PN weaning rate was similar to nonoperated children (p = 0.842). Conclusion: SBS children with short remaining SB, missing ICV, and SBA etiology are more likely while NEC patients are less likely than others to necessitate tapering surgery. Postoperative PN weaning rates were comparable to patients who initially had more favorable intestinal anatomy and adapted without surgery. (C) 2017 Elsevier Inc. All rights reserved.
Subject: Short bowel syndrome
Intestinal failure
Tapering surgery
Serial transverse enteroplasty
Longitudinal intestinal lengthening and tapering
SERIAL TRANSVERSE ENTEROPLASTY
BACTERIAL OVERGROWTH
RECONSTRUCTION SURGERY
PARENTERAL-NUTRITION
SMOOTH-MUSCLE
ENTERAL AUTONOMY
DATA REGISTRY
CHILDREN
FAILURE
GASTROSCHISIS
3126 Surgery, anesthesiology, intensive care, radiology
3123 Gynaecology and paediatrics
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