Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery

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http://hdl.handle.net/10138/297806

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Kormi , E , Snall , J , Koivusalo , A-M , Suominen , A L , Thoren , H & Tornwall , J 2017 , ' Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery ' , Journal of Oral and Maxillofacial Surgery , vol. 75 , no. 6 , pp. 1232-1237 . https://doi.org/10.1016/j.joms.2016.09.026

Title: Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery
Author: Kormi, Eeva; Snall, Johanna; Koivusalo, Anna-Maria; Suominen, Anna Liisa; Thoren, Hanna; Tornwall, Jyrki
Contributor: University of Helsinki, University of Helsinki
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
Date: 2017-06
Language: eng
Number of pages: 6
Belongs to series: Journal of Oral and Maxillofacial Surgery
ISSN: 0278-2391
URI: http://hdl.handle.net/10138/297806
Abstract: Purpose: To clarify the effect of systemic dexamethasone (DXM) on pain and postoperative opioid (oxycodone) consumption after blowout fracture surgery. Materials and Methods: A prospective randomized observer-blinded trial of 20 patients who had a blowout fracture requiring surgical intervention was conducted. Patients were randomly assigned to receive a total dose of intravenous DXM 30 mg perioperatively or no DXM (controls). Pain was assessed postoperatively using a 10-cm visual analog scale (VAS) each time analgesics (acetaminophen every 6 hours or oxycodone upon request) were administered. The VAS area under the curve (VAS AUC) for 24 hours postoperatively represented the outcome. Data were analyzed using chi(2) test, Student t test, 2-tailed Mann-Whitney U test, and linear regression, with a P value less than .05 indicating significance. Results: Patients with blowout fracture receiving perioperative systemic DXM exhibited a significantly lower average VAS AUC (P = .04). After controlling for other confounding variables, this result remained significant (P = .03). Conclusions: DXM appears to decrease postoperative pain and thus is recommended as a pre-emptive analgesic in blowout fracture surgery. (C) 2017 Published by Elsevier Inc on behalf of the American Association of Oral and Maxillofacial Surgeons
Subject: 3RD MOLAR SURGERY
CLINICAL-TRIAL
PAIN
CORTICOSTEROIDS
REMOVAL
METAANALYSIS
TRISMUS
TEETH
3126 Surgery, anesthesiology, intensive care, radiology
313 Dentistry
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