Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery

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Kormi , E , Snall , J , Koivusalo , A-M , Suominen , A L , Thoren , H & Tornwall , J 2017 , ' Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery ' , Journal of Oral and Maxillofacial Surgery , vol. 75 , no. 6 , pp. 1232-1237 .

Title: Analgesic Effect of Perioperative Systemic Dexamethasone on Blowout Fracture Surgery
Author: Kormi, Eeva; Snall, Johanna; Koivusalo, Anna-Maria; Suominen, Anna Liisa; Thoren, Hanna; Tornwall, Jyrki
Contributor organization: University of Helsinki
Department of Oral and Maxillofacial Diseases
Department of Diagnostics and Therapeutics
Anestesiologian yksikkö
HUS Perioperative, Intensive Care and Pain Medicine
HUS Head and Neck Center
Date: 2017-06
Language: eng
Number of pages: 6
Belongs to series: Journal of Oral and Maxillofacial Surgery
ISSN: 0278-2391
Abstract: Purpose: To clarify the effect of systemic dexamethasone (DXM) on pain and postoperative opioid (oxycodone) consumption after blowout fracture surgery. Materials and Methods: A prospective randomized observer-blinded trial of 20 patients who had a blowout fracture requiring surgical intervention was conducted. Patients were randomly assigned to receive a total dose of intravenous DXM 30 mg perioperatively or no DXM (controls). Pain was assessed postoperatively using a 10-cm visual analog scale (VAS) each time analgesics (acetaminophen every 6 hours or oxycodone upon request) were administered. The VAS area under the curve (VAS AUC) for 24 hours postoperatively represented the outcome. Data were analyzed using chi(2) test, Student t test, 2-tailed Mann-Whitney U test, and linear regression, with a P value less than .05 indicating significance. Results: Patients with blowout fracture receiving perioperative systemic DXM exhibited a significantly lower average VAS AUC (P = .04). After controlling for other confounding variables, this result remained significant (P = .03). Conclusions: DXM appears to decrease postoperative pain and thus is recommended as a pre-emptive analgesic in blowout fracture surgery. (C) 2017 Published by Elsevier Inc on behalf of the American Association of Oral and Maxillofacial Surgeons
3126 Surgery, anesthesiology, intensive care, radiology
313 Dentistry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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