Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes : The Cardiovascular Risk in Young Finns Study, 1980-2012

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Pulkki-Raback , L , Elovainio , M , Hakulinen , C , Lipsanen , J , Kubzansky , L D , Hintsanen , M , Savelieva , K , Serlachius , A , Magnussen , C G , Sabin , M A , Burgner , D P , Lehtimaki , T , Jokinen , E , Ronnemaa , T , Mikkila , V , Jula , A , Hutri-Kahonen , N , Viikari , J , Keltikangas-Jarvinen , L , Raitakari , O & Juonala , M 2017 , ' Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes : The Cardiovascular Risk in Young Finns Study, 1980-2012 ' , American Journal of Preventive Medicine , vol. 52 , no. 6 , pp. E157-E164 . https://doi.org/10.1016/j.amepre.2017.01.042

Title: Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes : The Cardiovascular Risk in Young Finns Study, 1980-2012
Author: Pulkki-Raback, Laura; Elovainio, Marko; Hakulinen, Christian; Lipsanen, Jari; Kubzansky, Laura D.; Hintsanen, Mirka; Savelieva, Kateryna; Serlachius, Anna; Magnussen, Costan G.; Sabin, Matthew A.; Burgner, David P.; Lehtimaki, Terho; Jokinen, Eero; Ronnemaa, Tapani; Mikkila, Vera; Jula, Antti; Hutri-Kahonen, Nina; Viikari, Jorma; Keltikangas-Jarvinen, Liisa; Raitakari, Olli; Juonala, Markus
Contributor: University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, University of Helsinki
University of Helsinki, Medicum
University of Helsinki, Psychosocial factors and health
University of Helsinki, Children's Hospital
University of Helsinki, Department of Food and Nutrition
University of Helsinki, University of Helsinki
Date: 2017-06
Language: eng
Number of pages: 8
Belongs to series: American Journal of Preventive Medicine
ISSN: 0749-3797
URI: http://hdl.handle.net/10138/297807
Abstract: Introduction: Type 2 diabetes is a public health concern, but psychosocial factors that may protect against the disease are unknown. This study examines whether a positive psychosocial environment in childhood is associated with lower risk for Type 2 diabetes in adulthood or healthier glucose trajectories over the life course, and whether BMI mediates the associations. Methods: A cohort of 3,596 Finnish children was followed into adulthood over 32 years. An overall positive psychosocial score, consisting of six subdomains, was measured at study baseline (1980). Relative risk ratios and multilevel growth curve modeling were used to examine associations of the psychosocial score with Type 2 diabetes (2012) and glucose trajectories (1986-2012). The mediating effect by BMI was examined using mediation analysis. The analyses were conducted between June 2015 and January 2016. Results: There was a 21% decrease in the rate of Type 2 diabetes (relative risk ratio, 0.79; 95% CI = 0.66, 0.94) for each 1-SD increase in the positive psychosocial score after adjustment for childhood cardiovascular risk factors and dietary behaviors. Adult BMI mediated 52% and weight gain mediated 25% of the association. The growth curve model showed healthier glucose trajectories (age X psychosocial score interaction, b = -0.01; p = 0.010) for participants with higher versus lower positive psychosocial score in childhood. Conclusions: Positive psychosocial environment in childhood seems to have beneficial influences on the risk for Type 2 diabetes over the life span. RCTs will be required to see if interventions directed at early-life circumstances are warranted. (C) 2017 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
Subject: CORONARY-HEART-DISEASE
CUMULATIVE RISK
HEALTH
COHORT
ABUSE
LIFE
OBESITY
ADOLESCENCE
ASSOCIATION
EXPERIENCES
3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
416 Food Science
515 Psychology
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