Effect of dimethyl sulfoxide on dentin collagen

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Mehtala , P , Pashley , D H & Tjaderhane , L 2017 , ' Effect of dimethyl sulfoxide on dentin collagen ' , Dental Materials , vol. 33 , no. 8 , pp. 915-922 . https://doi.org/10.1016/j.dental.2017.04.018

Title: Effect of dimethyl sulfoxide on dentin collagen
Author: Mehtala, P.; Pashley, D. H.; Tjaderhane, L.
Contributor organization: Clinicum
University of Helsinki
Department of Oral and Maxillofacial Diseases
HUS Head and Neck Center
Date: 2017-08
Language: eng
Number of pages: 8
Belongs to series: Dental Materials
ISSN: 0109-5641
DOI: https://doi.org/10.1016/j.dental.2017.04.018
URI: http://hdl.handle.net/10138/297827
Abstract: Objectives. Infiltration of adhesive on dentin matrix depends on interaction of surface and adhesive. Interaction depends on dentin wettability, which can be enhanced either by increasing dentin surface energy or lowering the surface energy of adhesive. The objective was to examine the effect of dimethyl sulfoxide (DMSO) on demineralized dentin wettability and dentin organic matrix expansion. Methods. Acid-etched human dentin was used for sessile drop contact angle measurement to test surface wetting on 1-5% DMSO-treated demineralized dentin surface, and linear variable differential transformer (LVDT) to measure expansion/shrinkage of dentinal matrix. DMSO-water binary liquids were examined for surface tension changes through concentrations from 0 to 100% DMSO. Kruskal-Wallis and Mann-Whitney tests were used to test the differences in dentin wettability, expansion and shrinkage, and Spearman test to test the correlation between DMSO concentration and water surface tension. The level of significance was p <0.05. Results. Pretreatment with 1-5% DMSO caused statistically significant concentration dependent increase in wetting: the immediate contact angles decreased by 11.8% and 46.6% and 60 s contact angles by 9.5% and 47.4% with 1% and 5% DMSO, respectively. DMSOwater mixtures concentration-dependently expanded demineralized dentin samples less than pure water, except with high (>80%) DMSO concentrations which expanded demineralized dentin more than water. Drying times of LVDT samples increased significantly with the use of DMSO. Significance. Increased dentin wettability may explain the previously demonstrated increase in adhesive penetration with DMSO-treated dentin, and together with the expansion of collagen matrix after drying may also explain previously observed increase in dentin adhesive bonding. (C) 2017 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
Subject: Wettability
Contact angle
Collagen expansion
Collagen shrinkage
313 Dentistry
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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