Coronary computed tomography angiography derived risk score in predicting cardiac events

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Uusitalo , V , Kamperidis , V , de Graaf , M A , Maaniitty , T , Stenstrom , I , Broersen , A , Dijkstra , J , Scholte , A J , Saraste , A , Bax , J J & Knuuti , J 2017 , ' Coronary computed tomography angiography derived risk score in predicting cardiac events ' , Journal of cardiovascular computed tomography , vol. 11 , no. 4 , pp. 274-280 .

Title: Coronary computed tomography angiography derived risk score in predicting cardiac events
Author: Uusitalo, Valtteri; Kamperidis, Vasileios; de Graaf, Michiel A.; Maaniitty, Teemu; Stenstrom, Iida; Broersen, Alexander; Dijkstra, Jouke; Scholte, Arthur J.; Saraste, Antti; Bax, Jeroen J.; Knuuti, Juhani
Contributor organization: University of Helsinki
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Date: 2017
Language: eng
Number of pages: 7
Belongs to series: Journal of cardiovascular computed tomography
ISSN: 1934-5925
Abstract: Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or data storage (n = 153) were excluded. Thus, final study group consisted of 508 patients aged 63 9 years. Coronary plaque location, severity and composition for each coronary segment were identified using automated CTA quantification software and integrated in a single CTA score (0-42). Adverse events (AE) including death, myocardial infarction (MI) and unstable angina (UA) were obtained from the national healthcare statistics. Results: There were a total of 20 (4%) AE during a median follow-up of 3.6 years (9 deaths, 5 MI and 6 UA). The CTA risk score was divided into tertiles: 0-6.7, 6.8-14.8 and > 14.8, respectively. All MI (n = 5) and most of the other AE occurred in the highest risk score tertile (3 vs. 3 vs. 14, p = 0.002). After correction for age and gender, the CTA risk score remained independently associated with AE. Conclusions: Comprehensive CIA risk score integrating the location, burden and composition of coronary atherosclerosis predicts future cardiac events in patients with suspected CAD. (C) 2017 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
Subject: Atherosclerosis
Coronary artery disease
Computed tomography angiography
Plaque characterization
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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