Coronary computed tomography angiography derived risk score in predicting cardiac events

Show simple item record Uusitalo, Valtteri Kamperidis, Vasileios de Graaf, Michiel A. Maaniitty, Teemu Stenstrom, Iida Broersen, Alexander Dijkstra, Jouke Scholte, Arthur J. Saraste, Antti Bax, Jeroen J. Knuuti, Juhani 2019-01-23T22:34:31Z 2021-12-17T22:02:27Z 2017
dc.identifier.citation Uusitalo , V , Kamperidis , V , de Graaf , M A , Maaniitty , T , Stenstrom , I , Broersen , A , Dijkstra , J , Scholte , A J , Saraste , A , Bax , J J & Knuuti , J 2017 , ' Coronary computed tomography angiography derived risk score in predicting cardiac events ' , Journal of cardiovascular computed tomography , vol. 11 , no. 4 , pp. 274-280 .
dc.identifier.other PURE: 87807917
dc.identifier.other PURE UUID: cbd5fd20-01e4-4b94-945e-d8db89efbdf2
dc.identifier.other WOS: 000404321500004
dc.identifier.other Scopus: 85018393122
dc.description.abstract Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or data storage (n = 153) were excluded. Thus, final study group consisted of 508 patients aged 63 9 years. Coronary plaque location, severity and composition for each coronary segment were identified using automated CTA quantification software and integrated in a single CTA score (0-42). Adverse events (AE) including death, myocardial infarction (MI) and unstable angina (UA) were obtained from the national healthcare statistics. Results: There were a total of 20 (4%) AE during a median follow-up of 3.6 years (9 deaths, 5 MI and 6 UA). The CTA risk score was divided into tertiles: 0-6.7, 6.8-14.8 and > 14.8, respectively. All MI (n = 5) and most of the other AE occurred in the highest risk score tertile (3 vs. 3 vs. 14, p = 0.002). After correction for age and gender, the CTA risk score remained independently associated with AE. Conclusions: Comprehensive CIA risk score integrating the location, burden and composition of coronary atherosclerosis predicts future cardiac events in patients with suspected CAD. (C) 2017 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of cardiovascular computed tomography
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Atherosclerosis
dc.subject Coronary artery disease
dc.subject Computed tomography angiography
dc.subject Plaque characterization
dc.subject SEVERITY
dc.subject PLAQUES
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Coronary computed tomography angiography derived risk score in predicting cardiac events en
dc.type Article
dc.contributor.organization University of Helsinki
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Clinicum
dc.contributor.organization HUS Medical Imaging Center
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1934-5925
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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