Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : an individual-based pooled analysis of 40 twin cohorts

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Silventoinen , K , Jelenkovic , A , Sund , R , Yokoyama , Y , Hur , Y-M , Cozen , W , Hwang , A E , Mack , T M , Honda , C , Inui , F , Iwatani , Y , Watanabe , M , Tomizawa , R , Pietilainen , K H , Rissanen , A , Siribaddana , S H , Hotopf , M , Sumathipala , A , Rijsdijk , F , Tan , Q , Zhang , D , Pang , Z , Piirtola , M , Aaltonen , S , Oncel , S Y , Aliev , F , Rebato , E , Hjelmborg , J B , Christensen , K , Skytthe , A , Kyvik , K O , Silberg , J L , Eaves , L J , Cutler , T L , Ordonana , J R , Sanchez-Romera , J F , Colodro-Conde , L , Song , Y-M , Yang , S , Lee , K , Franz , C E , Kremen , W S , Lyons , M J , Busjahn , A , Nelson , T L , Whitfield , K E , Kandler , C , Jang , K L , Gatz , M , Butler , D A , Stazi , M A , Fagnani , C , D'Ippolito , C , Duncan , G E , Buchwald , D , Martin , N G , Medland , S E , Montgomery , G W , Jeong , H-U , Swan , G E , Krasnow , R , Magnusson , P K , Pedersen , N L , Aslan , A K D , McAdams , T A , Eley , T C , Gregory , A M , Tynelius , P , Baker , L A , Tuvblad , C , Bayasgalan , G , Narandalai , D , Spector , T D , Mangino , M , Lachance , G , Burt , S A , Klump , K L , Harris , J R , Brandt , I , Nilsen , T S , Krueger , R F , Mcgue , M , Pahlen , S , Corley , R P , Huibregtse , B M , Bartels , M , van Beijsterveldt , C E M , Willemsen , G , Goldberg , J H , Rasmussen , F , Tarnoki , A D , Tarnoki , D L , Derom , C A , Vlietinck , R F , Loos , R J F , Hopper , J L , Sung , J , Maes , H H , Turkheimer , E , Boomsma , D I , Sorensen , T I A & Kaprio , J 2017 , ' Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : an individual-based pooled analysis of 40 twin cohorts ' , American Journal of Clinical Nutrition , vol. 106 , no. 2 , pp. 457-466 . https://doi.org/10.3945/ajcn.117.153643

Title: Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region : an individual-based pooled analysis of 40 twin cohorts
Author: Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Yokoyama, Yoshie; Hur, Yoon-Mi; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Honda, Chika; Inui, Fujio; Iwatani, Yoshinori; Watanabe, Mikio; Tomizawa, Rie; Pietilainen, Kirsi H.; Rissanen, Aila; Siribaddana, Sisira H.; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Piirtola, Maarit; Aaltonen, Sari; Oncel, Sevgi Y.; Aliev, Fazil; Rebato, Esther; Hjelmborg, Jacob B.; Christensen, Kaare; Skytthe, Axel; Kyvik, Kirsten O.; Silberg, Judy L.; Eaves, Lindon J.; Cutler, Tessa L.; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Song, Yun-Mi; Yang, Sarah; Lee, Kayoung; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Busjahn, Andreas; Nelson, Tracy L.; Whitfield, Keith E.; Kandler, Christian; Jang, Kerry L.; Gatz, Margaret; Butler, David A.; Stazi, Maria A.; Fagnani, Corrado; D'Ippolito, Cristina; Duncan, Glen E.; Buchwald, Dedra; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Jeong, Hoe-Uk; Swan, Gary E.; Krasnow, Ruth; Magnusson, Patrik Ke; Pedersen, Nancy L.; Aslan, Anna K. Dahl; McAdams, Tom A.; Eley, Thalia C.; Gregory, Alice M.; Tynelius, Per; Baker, Laura A.; Tuvblad, Catherine; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Spector, Timothy D.; Mangino, Massimo; Lachance, Genevieve; Burt, S. Alexandra; Klump, Kelly L.; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas S.; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Corley, Robin P.; Huibregtse, Brooke M.; Bartels, Meike; van Beijsterveldt, Catharina E. M.; Willemsen, Gonneke; Goldberg, Jack H.; Rasmussen, Finn; Tarnoki, Adam D.; Tarnoki, David L.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Hopper, John L.; Sung, Joohon; Maes, Hermine H.; Turkheimer, Eric; Boomsma, Dorret I.; Sorensen, Thorkild I. A.; Kaprio, Jaakko
Contributor organization: Department of Social Research (2010-2017)
Sociology
Center for Population, Health and Society
Clinicum
Kirsi Hannele Pietiläinen / Principal Investigator
Diabetes and Obesity Research Program
Research Programs Unit
Department of Medicine
Institute for Molecular Medicine Finland
Department of Public Health
Jaakko Kaprio / Principal Investigator
Population Research Unit (PRU)
HUS Psychiatry
HUS Internal Medicine and Rehabilitation
HUS Abdominal Center
Genetic Epidemiology
Date: 2017-08
Language: eng
Number of pages: 10
Belongs to series: American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: https://doi.org/10.3945/ajcn.117.153643
URI: http://hdl.handle.net/10138/297911
Abstract: Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood. Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity. Design: We used genetic structural equation modeling to analyze BMI in twins >= 20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs). Results: The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 2029 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70-79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20-29 to 60-69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI. Conclusions: The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.
Subject: BMI
adults
genetics
twins
international comparisons
BODY-MASS INDEX
ANTHROPOMETRICAL MEASURES
COLLABORATIVE PROJECT
CODATWINS PROJECT
OBESITY EPIDEMIC
HERITABILITY
TRAITS
COMPONENTS
INSIGHTS
TRACKING
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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