Challenges in endometriosis miRNA studies - From tissue heterogeneity to disease specific miRNAs

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Saare , M , Rekker , K , Laisk-Podar , T , Rahmioglu , N , Zondervan , K , Salumets , A , Götte , M & Peters , M 2017 , ' Challenges in endometriosis miRNA studies - From tissue heterogeneity to disease specific miRNAs ' , Biochimica et Biophysica Acta. Molecular Basis of Disease , vol. 1863 , no. 9 , pp. 2282-2292 . https://doi.org/10.1016/j.bbadis.2017.06.018

Title: Challenges in endometriosis miRNA studies - From tissue heterogeneity to disease specific miRNAs
Author: Saare, Merli; Rekker, Kadri; Laisk-Podar, Triin; Rahmioglu, Nilufer; Zondervan, Krina; Salumets, Andres; Götte, Martin; Peters, Maire
Contributor: University of Helsinki, Clinicum
Date: 2017-09
Language: eng
Number of pages: 11
Belongs to series: Biochimica et Biophysica Acta. Molecular Basis of Disease
ISSN: 0925-4439
URI: http://hdl.handle.net/10138/297925
Abstract: In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large number of dysregulated miRNAs have been reported. However, the concordance between the result of different studies has remained small. One potential explanation for limited overlap between the proposed disease-related miRNAs could be the heterogeneity in tissue composition, as some studies have compared highly heterogeneous whole-lesion biopsies with endometrial tissue, some have compared the endometrium from patients and controls, and some have used pure cell fractions isolated from lesions and endometrium. This review focuses on the results of published miRNA studies in endometriosis to reveal the potential impact of tissue heterogeneity on the discovery of disease-specific miRNA alterations in endometriosis. Additionally, functional studies that explore the roles of endometriosis-involved miRNAs are discussed.
Subject: Endometriosis
Endometrium
Microarray
MicroRNA
Stroma
Tissue heterogeneity
EPITHELIAL-MESENCHYMAL TRANSITION
LASER CAPTURE MICRODISSECTION
MICRORNA EXPRESSION PROFILE
MIGRATION INHIBITORY FACTOR
STROMAL CELLS
EUTOPIC ENDOMETRIUM
GENE-EXPRESSION
CANCER-CELLS
APOPTOSIS
PATHOGENESIS
3123 Gynaecology and paediatrics
1182 Biochemistry, cell and molecular biology
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