Breast implant-associated anaplastic large cell lymphoma - From diagnosis to treatment

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Kaartinen , I , Sunela , K , Alanko , J , Hukkinen , K , Karjalainen-Lindsberg , M -L & Svarvar , C 2017 , ' Breast implant-associated anaplastic large cell lymphoma - From diagnosis to treatment ' , European Journal of Surgical Oncology , vol. 43 , no. 8 , pp. 1385-1392 .

Title: Breast implant-associated anaplastic large cell lymphoma - From diagnosis to treatment
Author: Kaartinen, I.; Sunela, K.; Alanko, J.; Hukkinen, K.; Karjalainen-Lindsberg, M. -L.; Svarvar, C.
Contributor organization: Department of Diagnostics and Therapeutics
University of Helsinki
HUS Medical Imaging Center
Department of Pathology
II kirurgian klinikka
Plastiikkakirurgian yksikkö
Department of Surgery
Department of Oncology
HUS Comprehensive Cancer Center
Date: 2017-08
Language: eng
Number of pages: 8
Belongs to series: European Journal of Surgical Oncology
ISSN: 0748-7983
Abstract: Breast lymphomas comprise a rare group of malignant breast tumors. Among these, a new entity has emerged as a potentially under diagnosed disease. Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) most often manifests as a late periprosthetic effusion between 1 and 10 years after the implantation of silicone or saline-filled breast prostheses. BI-ALCL is an anaplastic lymphoma kinase-negative T-cell lymphoma that has a distinctively different clinical course than other breast lymphomas or ALCLs. Diagnosis is based on aspiration of the effusion around the implant and CD30 positivity of the sample. Every periprosthetic effusion after breast augmentation or reconstruction using implants should be considered as potential BI-ALCL until proven otherwise. The majority of cases at diagnosis are in the in situ stage, i.e., confined to the lumen around the prosthesis. Most patients have an excellent prognosis when complete removal of the capsule and prosthesis with negative margins is achieved surgically. Some patients, however, develop infiltrative disease with a potentially life-threatening clinical course. Treatment planning regarding the extent of surgery and role of adjuvant therapy, especially in advanced cases, requires further investigation. (c) 2017 Elsevier Ltd, BASO-The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Subject: ALCL
ALK-negative lymphoma
Breast implants
Cytotoxic c-cell
3126 Surgery, anesthesiology, intensive care, radiology
3122 Cancers
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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