Prognostic biomarkers for oral tongue squamous cell carcinoma : a systematic review and meta-analysis

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http://hdl.handle.net/10138/297944

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Almangush , A , Heikkinen , I , Mäkitie , A A , Coletta , R D , Läärä , E , Leivo , I & Salo , T 2017 , ' Prognostic biomarkers for oral tongue squamous cell carcinoma : a systematic review and meta-analysis ' , British Journal of Cancer , vol. 117 , no. 6 , pp. 856-866 . https://doi.org/10.1038/bjc.2017.244

Title: Prognostic biomarkers for oral tongue squamous cell carcinoma : a systematic review and meta-analysis
Author: Almangush, Alhadi; Heikkinen, Ilkka; Mäkitie, Antti A.; Coletta, Ricardo D.; Läärä, Esa; Leivo, Ilmo; Salo, Tuula
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, HUSLAB
Date: 2017-09-05
Language: eng
Number of pages: 11
Belongs to series: British Journal of Cancer
ISSN: 0007-0920
URI: http://hdl.handle.net/10138/297944
Abstract: Background: Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. Methods: A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results. Results: A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread. Conclusions: Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. The value of two biomarkers (VEGFA and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines.
Subject: immunohistochemistry
biomarker
prognosis
oral tongue cancer
LYMPH-NODE METASTASIS
POOR-PROGNOSIS
CANCER
EXPRESSION
P16(INK4A)
SURVIVAL
MARKERS
P53
IMMUNOEXPRESSION
OVEREXPRESSION
3122 Cancers
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