Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms

Show full item record



Permalink

http://hdl.handle.net/10138/297985

Citation

Määttä , A M , Kotaniemi-Syrjänen , A , Malmström , K , Malmberg , L P , Sundvall , J , Pelkonen , A S & Makela , M J 2017 , ' Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms ' , Annals of Allergy, Asthma, & Immunology , vol. 119 , no. 3 , pp. 227-231 . https://doi.org/10.1016/j.anai.2017.06.014

Title: Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms
Author: Määttä, Anette M.; Kotaniemi-Syrjänen, Anne; Malmström, Kristiina; Malmberg, L. Pekka; Sundvall, Jouko; Pelkonen, Anna S.; Makela, Mika J.
Contributor: University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Clinicum
Date: 2017-09
Language: eng
Number of pages: 5
Belongs to series: Annals of Allergy, Asthma, & Immunology
ISSN: 1081-1206
URI: http://hdl.handle.net/10138/297985
Abstract: Background: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. Objective: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. Methods: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test. In addition, skin prick tests were performed and serum 25-hydroxyvitamin D (S-25-OHD), hs-CRP, total immunoglobulin E, and blood eosinophil levels were determined. Results: S-25-OHD was lowest in infants with blood eosinophilia and AHR (n = 10) compared with those with eosinophilia only (n = 6) or AHR only (n = 50) or those with neither (n = 13; P = .035). Moreover, vitamin D insufficiency (S-25-OHD <50 nmol/L) was most common in infants with blood eosinophilia and AHR (P = .041). Serum hs-CRP was lower in infants with recurrent physician-diagnosed wheezing (P = .048) and in those with blood eosinophilia (P = .015) than in infants without these characteristics and was not associated with S-25-OHD or AHR. S-25-OHD levels were significantly lower (median 54 nmol/L) during the autumn-winter season than in the spring-summer season (median 63 nmol/L; P = .026). Conclusion: Vitamin D insufficiency could underlie eosinophilia and AHR in infants with troublesome lung symptoms, whereas hs-CRPemediated low-grade systemic inflammation is rare in early childhood wheezing. (C) 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Subject: CHILDHOOD ASTHMA
LUNG-FUNCTION
PRESCHOOL-CHILDREN
INFLAMMATION
SEVERITY
MARKERS
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1081120617305021_main.pdf 365.8Kb PDF View/Open
Final_Manuscript_Anette_Maatta_13122019.pdf 268.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record