Toxoplasma gondii infection and common mental disorders in the Finnish general population

Show full item record



Permalink

http://hdl.handle.net/10138/298044

Citation

Suvisaari , J , Torniainen-Holm , M , Lindgren , M , Harkanen , T & Yolken , R H 2017 , ' Toxoplasma gondii infection and common mental disorders in the Finnish general population ' , Journal of Affective Disorders , vol. 223 , pp. 20-25 . https://doi.org/10.1016/j.jad.2017.07.020

Title: Toxoplasma gondii infection and common mental disorders in the Finnish general population
Author: Suvisaari, Jaana; Torniainen-Holm, Minna; Lindgren, Maija; Harkanen, Tommi; Yolken, Robert H.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-12
Language: eng
Number of pages: 6
Belongs to series: Journal of Affective Disorders
ISSN: 0165-0327
URI: http://hdl.handle.net/10138/298044
Abstract: Objective: We investigated whether T. gondii seropositivity is associated with 12-month depressive, anxiety and alcohol use disorders and current depressive symptoms and whether inflammation, measured by C-reactive protein (CRP) level, explains these associations. Method: Health 2000 study (BRIF8901), conducted in years 2000-2001, is based on a nationally representative sample of Finns aged 30 and above, with 7112 participants and 88.6% response rate. DSM-IV depressive, anxiety and alcohol use disorders were assessed with the Composite International Diagnostic Interview and depressive symptoms with the Beck Depressive Inventory (BDI-21). We used logistic regression to investigate the association of T. gondii seropositivity with mental disorders and linear regression with BDI-21 scores. Results: T. gondii seroprevalence was significantly associated with 12-month generalized anxiety disorder but not with other anxiety, depressive or alcohol use disorders. T. gondii seropositivity was associated with higher BDI-21 scores (beta 0.56, 95% CI 0.12-1.00, P = 0.013) and with having a comorbid depressive and anxiety disorder (OR 1.86, 95% CI 1.16-2.97, P = 0.010). Higher CRP levels were associated with these outcomes and with T. gondii seropositivity, but adjusting for CRP did not change the effect of T. gondii seropositivity. Limitations: Cross-sectional study design with no information on the timing of T. gondii infection. Conclusion: T. gondii seropositivity is associated with generalized anxiety disorder, depressive symptoms and comorbid depressive and anxiety disorders, which is not mediated by inflammation.
Subject: Generalized anxiety disorder
Anxiety disorders
Depressive disorders
Alcohol use disorders
C-reactive protein
Toxoplasma gondii
DEPRESSION
ANXIETY
SCHIZOPHRENIA
ASSOCIATION
HEALTH
ADULTS
MOOD
METAANALYSIS
AGGRESSION
BURDEN
3112 Neurosciences
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0165032717302951_main.pdf 251.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record