Serum fasting GLP-1 and GLP-2 associate with intestinal adaptation in pediatric onset intestinal failure

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Mutanen , A & Pakarinen , M P 2017 , ' Serum fasting GLP-1 and GLP-2 associate with intestinal adaptation in pediatric onset intestinal failure ' , Clinical Nutrition , vol. 36 , no. 5 , pp. 1349-1354 . https://doi.org/10.1016/j.clnu.2016.09.002

Title: Serum fasting GLP-1 and GLP-2 associate with intestinal adaptation in pediatric onset intestinal failure
Author: Mutanen, Annika; Pakarinen, Mikko P.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Lastenkirurgian yksikkö
Date: 2017-10
Language: eng
Number of pages: 6
Belongs to series: Clinical Nutrition
ISSN: 0261-5614
URI: http://hdl.handle.net/10138/298048
Abstract: Aim: Glukagon-like-peptide-1 (GLP-1) and -2 (GLP-2), produced by intestinal L-cells, are key hormones regulating intestinal transit, secretion, absorption, and mucosal growth. We evaluated nai ve fasting serum GLP-1 and GLP-2 levels in pediatric intestinal failure (IF). Methods: Fifty-five IF patients with median age 4.2 (IQR 1.3-12) years and 47 matched healthy controls underwent measurement of fasting serum GLP-1 and GLP-2. Results: Serum GLP-2 [19.9 (13.8-27.9) vs 11.6 (7.0-18.6) ng/mL, P <0.001], but not GLP-1 [6.1 (4.0-15.7) vs 6.4 (3.9-10.7) ng/mL, P = 0.976], levels were increased in IF patients. Serum GLP-2 concentrations were higher in patients with small bowel -colic continuity [21.1 (15.0-30.7) ng/mL] compared to patients with an endostomy [10.4 (6.6-17.9) ng/mL, P = 0.028], whereas no association with preservation of ileum or ileocecal valve was observed. During PN delivery, GLP-2 inversely associated with remaining small bowel length (r = -0.500, P = 0.041) and frequency of PN infusions (r = -0.549, P = 0.042). Serum GLP-1 levels were lower in patients receiving PN currently [4.1 (2.8-5.1)] compared to patients, who had weaned off PN [6.5 (5.1-21.1), P = 0.005],. and correlated positively with duration of PN (r = -0.763, P = 0.002) and negatively with percentage parenteral energy requirement (r = -0.716, P = 0.006). Conclusions: In pediatric IF, serum GLP-2 levels increase in patients with small bowel -colic continuity proportionally to the length of resected small intestine. Increase in serum GLP-1 and GLP-2 levels paralleled reducing requirement for parenteral support. These findings support regulation of intestinal adaption by GLP-2 and GLP-1 in children with IF. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Subject: Parenteral nutrition
Short bowel syndrome
Children
SHORT-BOWEL SYNDROME
GLUCAGON-LIKE PEPTIDE-2
PARENTERAL-NUTRITION
TEDUGLUTIDE
CHILDREN
CHOLESTASIS
ABSORPTION
OUTCOMES
3123 Gynaecology and paediatrics
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