Altered N100-potential associates with working memory impairment in Parkinson's disease

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dc.contributor.author Annanmaki, Tua
dc.contributor.author Palmu, Kirsi
dc.contributor.author Murros, Kari
dc.contributor.author Partanen, Juhani
dc.date.accessioned 2019-01-23T22:37:51Z
dc.date.available 2021-12-17T22:02:37Z
dc.date.issued 2017-10
dc.identifier.citation Annanmaki , T , Palmu , K , Murros , K & Partanen , J 2017 , ' Altered N100-potential associates with working memory impairment in Parkinson's disease ' , Journal of Neural Transmission , vol. 124 , no. 10 , pp. 1197-1203 . https://doi.org/10.1007/s00702-017-1758-z
dc.identifier.other PURE: 91430834
dc.identifier.other PURE UUID: b8d21e32-2623-47bf-a311-88122f90cb7b
dc.identifier.other WOS: 000411938200005
dc.identifier.other Scopus: 85023750158
dc.identifier.other ORCID: /0000-0001-5407-1291/work/39204295
dc.identifier.uri http://hdl.handle.net/10138/298057
dc.description.abstract The diagnosis of cognitive impairment and dementia often occurring with Parkinson's disease (PD) is still based on the clinical picture and neuropsychological examination. Ancillary methods to detect cognitive decline in these patients are, therefore, needed. Alterations in the latencies and amplitudes of evoked response potential (ERP) components N100 and P200 have been described in PD. Due to limited number of studies their relation to cognitive deficits in PD remains obscure. The present study was designed to examine if alterations in the N100- and P200-potentials associate with neuropsychological impairment in PD. EEG-ERP was conducted to 18 PD patients and 24 healthy controls. The patients underwent a thorough neuropsychological evaluation. The controls were screened for cognitive impairment with Consortium to Establish Alzheimer's disease (CERAD)-testing and a normal result were required to be included in the study. The N100-latency was prolonged in the patients compared to the controls (p = 0.05). In the patients, the N100 latency correlated significantly with a visual working memory task (p = 0.01). Also N100 latency was prolonged and N100 amplitude habituation diminished in the patients achieving poorly in this task. We conclude that prolonged N100-latency and diminished amplitude habituation associate with visual working memory impairment in PD. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Journal of Neural Transmission
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Evoked response potential
dc.subject Cognition
dc.subject Parkinson's disease
dc.subject EVENT-RELATED POTENTIALS
dc.subject MILD COGNITIVE IMPAIRMENT
dc.subject DIAGNOSTIC-CRITERIA
dc.subject BASAL GANGLIA
dc.subject DYSFUNCTION
dc.subject DEMENTIA
dc.subject ATTENTION
dc.subject HABITUATION
dc.subject ABILITY
dc.subject PREDICT
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Altered N100-potential associates with working memory impairment in Parkinson's disease en
dc.type Article
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Department of Neurosciences
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization Kliinisen neurofysiologian yksikkö
dc.contributor.organization HUS Medical Imaging Center
dc.contributor.organization HUS Neurocenter
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s00702-017-1758-z
dc.relation.issn 0300-9564
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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