Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Show full item record



Permalink

http://hdl.handle.net/10138/298061

Citation

Kootte , R S , Levin , E , Salojarvi , J , Smits , L P , Hartstra , A V , Udayappan , S D , Hermes , G , Bouter , K E , Koopen , A M , Holst , J J , Knop , F K , Blaak , E E , Zhao , J , Smidt , H , Harms , A C , Hankemeijer , T , Bergman , J J G H M , Romijn , H A , Schaap , F G , Damink , S W M O , Ackermans , M T , Dallinga-Thie , G M , Zoetendal , E , de Vos , W M , Serlie , M J , Stroes , E S G , Groen , A K & Nieuwdorp , M 2017 , ' Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition ' , Cell Metabolism , vol. 26 , no. 4 , pp. 611-+ . https://doi.org/10.1016/j.cmet.2017.09.008

Title: Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Author: Kootte, Ruud S.; Levin, Evgeni; Salojarvi, Jarkko; Smits, Loek P.; Hartstra, Annick V.; Udayappan, Shanti D.; Hermes, Gerben; Bouter, Kristien E.; Koopen, Annefleur M.; Holst, Jens J.; Knop, Filip K.; Blaak, Ellen E.; Zhao, Jing; Smidt, Hauke; Harms, Amy C.; Hankemeijer, Thomas; Bergman, Jacques J. G. H. M.; Romijn, Hans A.; Schaap, Frank G.; Damink, Steven W. M. Olde; Ackermans, Mariette T.; Dallinga-Thie, Geesje M.; Zoetendal, Erwin; de Vos, Willem M.; Serlie, Mireille J.; Stroes, Erik S. G.; Groen, Albert K.; Nieuwdorp, Max
Contributor: University of Helsinki, Biosciences
University of Helsinki, Medicum
Date: 2017-10-03
Language: eng
Number of pages: 15
Belongs to series: Cell Metabolism
ISSN: 1550-4131
URI: http://hdl.handle.net/10138/298061
Abstract: The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as gamma-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.
Subject: RECURRENT CLOSTRIDIUM-DIFFICILE
BILE-ACID METABOLISM
CHAIN FATTY-ACIDS
GUT MICROBIOTA
MARKERS
OBESITY
TRANSPLANTATION
LACTOBACILLUS
SELECTION
BACTERIA
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1550413117305594_main.pdf 1.911Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record