Sleep and slow-wave activity in depressed adolescent boys : a preliminary study

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http://hdl.handle.net/10138/298086

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Santangeli , O , Porkka-Heiskanen , T , Virkkala , J , Castaneda , A E , Marttunen , M , Paunio , T & Urrila , A S 2017 , ' Sleep and slow-wave activity in depressed adolescent boys : a preliminary study ' , Sleep Medicine , vol. 38 , pp. 24-30 . https://doi.org/10.1016/j.sleep.2017.06.029

Title: Sleep and slow-wave activity in depressed adolescent boys : a preliminary study
Author: Santangeli, Olena; Porkka-Heiskanen, Tarja; Virkkala, Jussi; Castaneda, Anu E.; Marttunen, Mauri; Paunio, Tiina; Urrila, Anna S.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-10
Language: eng
Number of pages: 7
Belongs to series: Sleep Medicine
ISSN: 1389-9457
URI: http://hdl.handle.net/10138/298086
Abstract: Objective: Adolescence is a vulnerable period of life that is characterized by increasing incidence of depression. Sleep disturbance is one of the diagnostic symptoms of depressive disorder. Adolescence is also characterized by dramatic maturational changes in sleep and its regulation. The goal of this study was to assess sleep macroarchitecture and slow-wave activity (SWA) in depressed adolescent boys. Methods: Eight non-medicated adolescent boys meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for depressive disorder and 10 age-matched healthy controls (average age 16.0 years) underwent polysomnography in their home environment for two consecutive nights. Sleep macroarchitecture, SWA, and SWA dissipation were assessed in all subjects. Results: Depressed boys showed a flattened pattern of SWA dissipation through the night. SWA power was lower during the first non-rapid eye movement (NREM) episode in the frontal derivation and higher during the third NREM episode in the central derivation in the group of depressed boys as compared to healthy boys. The SWA dissipation pattern correlated with the severity of depressive symptoms, and the correlation was strongest in the frontal derivation. In addition, total sleep time was shorter in patients as compared to the control group, but no other differences were found in the macroarchitecture of sleep. Conclusion: Depression in adolescent boys is characterized by more evenly distributed SWA through the night as compared to healthy subjects, and we showed for the first time that this pattern of SWA distribution is associated with severity of depressive symptoms. These findings suggest that homeostatic regulation of sleep may be impaired in adolescent depression. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Sleep
Depression
Adolescence
Slow-wave activity
Slow-wave activity dissipation
Polysomnography
EEG POWER-DENSITY
MAJOR DEPRESSION
YOUNG-ADULTS
DEVELOPMENTAL-CHANGES
BRAIN MATURATION
HEALTHY CONTROLS
MOOD DISORDERS
EARLY-ONSET
TIME-COURSE
PREVALENCE
3112 Neurosciences
3124 Neurology and psychiatry
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