Asthmatic farm children show increased CD3(+) CD8(low) T-cells compared to non-asthmatic farm children

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Twardziok , M , Schroder , P C , Krusche , J , Casaca , V I , Illi , S , Bock , A , Loss , G J , Kabesch , M , Toncheva , A A , Roduit , C , Depner , M , Genuneit , J , Renz , H , Roponen , M , Weber , J , Braun-Fahrlander , C , Riedler , J , Lauener , R , Vuitton , D A , Dalphin , J-C , Pekkanen , J , von Mutius , E , Schaub , B , PASTURE Study Grp , Hyvarinen , A , Karvonen , A M , Kirjavainen , P V , Remes , S , Kaulek , V , Dalphin , M-L , Ege , M , Pfefferle , P I & Doekes , G 2017 , ' Asthmatic farm children show increased CD3(+) CD8(low) T-cells compared to non-asthmatic farm children ' , Clinical Immunology , vol. 183 , pp. 285-292 . https://doi.org/10.1016/j.clim.2017.09.009

Title: Asthmatic farm children show increased CD3(+) CD8(low) T-cells compared to non-asthmatic farm children
Author: Twardziok, Monika; Schroder, Paul C.; Krusche, Johanna; Casaca, Vera I.; Illi, Sabina; Bock, Andreas; Loss, Georg J.; Kabesch, Michael; Toncheva, Antoaneta A.; Roduit, Caroline; Depner, Martin; Genuneit, Jon; Renz, Harald; Roponen, Marjut; Weber, Juliane; Braun-Fahrlander, Charlotte; Riedler, Josef; Lauener, Roger; Vuitton, Dominique Angele; Dalphin, Jean-Charles; Pekkanen, Juha; von Mutius, Erika; Schaub, Bianca; PASTURE Study Grp; Hyvarinen, Anne; Karvonen, Anne M.; Kirjavainen, Pirkka V.; Remes, Sami; Kaulek, Vincent; Dalphin, Marie-Laure; Ege, Markus; Pfefferle, Petra I.; Doekes, Gert
Contributor: University of Helsinki, Clinicum
Date: 2017-10
Language: eng
Number of pages: 8
Belongs to series: Clinical Immunology
ISSN: 1521-6616
URI: http://hdl.handle.net/10138/298124
Abstract: Several studies report an important role of CD8(+) cytotoxic T-cells in atopy. Farm children show protection against atopy development, partly explained by CD4(+) T-cell subtypes. Additional effects of CD8(+) T-cells are unknown being investigated in this study within the PASTURE/EFRAIM birth cohort in PBMCs from farming and non-farming 6-year-old (N = 76) German children. CD3(+) CD8(+) CD25(+) T-cells were analyzed by flow cytometry. Genotyping of 17q21 locus-SNPs associated with childhood asthma was performed. No differences in CD8(+) T-cell subsets were seen between farmers and non-farmers regardless of asthma. Among farm children, asthmatics displayed increased CD3(+) CD8(low)(CD25(+)) T-cells compared to non-asthmatics. Asthmatic farm children exhibited a lower PI-induced stimulatory capacity of CD3(+) CD8(low)(CD25(+)) cells and a lower IFN-gamma secretion than non-asthmatic farm children. Among farm children with GSDMB and ORMDL3 risk alleles, asthmatics displayed higher CD3(+) CD8(low) cells than non-asthmatics. Our data indicates a specific role of CD8(low) T-cells in asthmatic farm children. (C) 2017 Elsevier Inc. All rights reserved.
Subject: CD8(+)
CD8(low)
Childhood
Farm-exposure
BROWN-NORWAY RATS
ALLERGIC DISEASE
CHILDHOOD ASTHMA
EXPOSURE
EXPRESSION
PHENOTYPE
WHEEZE
RISK
AGE
DIFFERENTIATION
3121 General medicine, internal medicine and other clinical medicine
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