The genetics underlying idiopathic ventricular fibrillation : A special role for catecholaminergic polymorphic ventricular tachycardia?

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Leinonen , J T , Crotti , L , Djupsjobacka , A , Castelletti , S , Junna , N , Ghidoni , A , Tuiskula , A M , Spazzolini , C , Dagradi , F , Viitasalo , M , Kontula , K , Kotta , M-C , Widen , E , Swan , H & Schwartz , P J 2018 , ' The genetics underlying idiopathic ventricular fibrillation : A special role for catecholaminergic polymorphic ventricular tachycardia? ' , International Journal of Cardiology , vol. 250 , pp. 139-145 . https://doi.org/10.1016/j.ijcard.2017.10.016

Title: The genetics underlying idiopathic ventricular fibrillation : A special role for catecholaminergic polymorphic ventricular tachycardia?
Author: Leinonen, Jaakko T.; Crotti, Lia; Djupsjobacka, Aurora; Castelletti, Silvia; Junna, Nella; Ghidoni, Alice; Tuiskula, Annukka M.; Spazzolini, Carla; Dagradi, Federica; Viitasalo, Matti; Kontula, Kimmo; Kotta, Maria-Christina; Widen, Elisabeth; Swan, Heikki; Schwartz, Peter J.
Contributor organization: Institute for Molecular Medicine Finland
University of Helsinki
Kardiologian yksikkö
HUS Heart and Lung Center
Kimmo Kontula Research Group
Clinicum
Department of Medicine
HUS Internal Medicine and Rehabilitation
Elisabeth Ingrid Maria Widen / Principal Investigator
Centre of Excellence in Complex Disease Genetics
Genomic Discoveries and Clinical Translation
Date: 2018-01-01
Language: eng
Number of pages: 7
Belongs to series: International Journal of Cardiology
ISSN: 0167-5273
DOI: https://doi.org/10.1016/j.ijcard.2017.10.016
URI: http://hdl.handle.net/10138/298140
Abstract: Background: Ventricular fibrillation (VF) is a major cause of sudden cardiac death. In some cases clinical investigations fail to identify the underlying cause and the event is classified as idiopathic (IVF). Since mutations in arrhythmia-associated genes frequently determine arrhythmia susceptibility, screening for disease-predisposing variants could improve IVF diagnostics. Methods and results: The study included 76 Finnish and Italian patients with a mean age of 31.2 years at the time of the VF event, collected between the years 1996-2016 and diagnosed with idiopathic, out-of-hospital VF. Using whole-exome sequencing (WES) and next-generation sequencing (NGS) approaches, we aimed to identify genetic variants potentially contributing to the life-threatening arrhythmias of these patients. Combining the results from the two study populations, we identified pathogenic or likely pathogenic variants residing in the RYR2, CACNA1C and DSP genes in 7 patients (9%). Most of them(5, 71%) were found in the RYR2 gene, associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). These genetic findings prompted clinical investigations leading to disease reclassification. Additionally, in 9 patients (11.8%) we detected 10 novel or extremely rare (MAF <0.005%) variants that were classified as of unknown significance (VUS). Conclusion: The results of our study suggest that a subset of patients originally diagnosed with IVF may carry clinically-relevant variants in genes associated with cardiac channelopathies and cardiomyopathies. Although misclassification of other cardiac channelopathies as IVF appears rare, our findings indicate that the possibility of CPVT as the underlying disease entity should be carefully evaluated in IVF patients. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Idiopathic ventricular fibrillation
Genetics
Catecholaminergic polymorphic ventricular tachycardia
RYR2
Genetic testing
LONG-QT SYNDROME
CARDIAC-ARREST
SEQUENCE VARIANTS
HYPERTROPHIC CARDIOMYOPATHY
FOLLOW-UP
MUTATIONS
GUIDELINES
DISEASE
CHANNEL
ASSOCIATION
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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