Long-Term Outcomes of Cord Blood Transplantation from an HLA-Identical Sibling for Patients with Bone Marrow Failure Syndromes : A Report From Eurocord, Cord Blood Committee and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation

Show full item record



Permalink

http://hdl.handle.net/10138/298152

Citation

Pagliuca , S , de Latour , R P , Volt , F , Locatelli , F , Zecca , M , Dalle , J-H , Comoli , P , Vettenranta , K , Angel Diaz , M , Reuven , O , Bertrand , Y , Diaz de Heredia , C , Nagler , A , Ghavamzadeh , A , Sufliarska , S , Lawson , S , Kenzey , C , Rocha , V , Dufour , C , Gluckman , E , Passweg , J & Ruggeri , A 2017 , ' Long-Term Outcomes of Cord Blood Transplantation from an HLA-Identical Sibling for Patients with Bone Marrow Failure Syndromes : A Report From Eurocord, Cord Blood Committee and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation ' , Biology of Blood and Marrow Transplantation , vol. 23 , no. 11 , pp. 1939-1948 . https://doi.org/10.1016/j.bbmt.2017.08.004

Title: Long-Term Outcomes of Cord Blood Transplantation from an HLA-Identical Sibling for Patients with Bone Marrow Failure Syndromes : A Report From Eurocord, Cord Blood Committee and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation
Author: Pagliuca, Simona; de Latour, Regis Peffault; Volt, Fernanda; Locatelli, Franco; Zecca, Marco; Dalle, Jean-Hugues; Comoli, Patrizia; Vettenranta, Kim; Angel Diaz, Miguel; Reuven, Or; Bertrand, Yves; Diaz de Heredia, Cristina; Nagler, Arnon; Ghavamzadeh, Ardeshir; Sufliarska, Sabina; Lawson, Sarah; Kenzey, Chantal; Rocha, Vanderson; Dufour, Carlo; Gluckman, Eliane; Passweg, Jakob; Ruggeri, Annalisa
Contributor: University of Helsinki, Clinicum
Date: 2017-11
Language: eng
Number of pages: 10
Belongs to series: Biology of Blood and Marrow Transplantation
ISSN: 1083-8791
URI: http://hdl.handle.net/10138/298152
Abstract: Cord blood transplantation (CBT) from HLA-identical siblings is an attractive option for patients with bone marrow failure (BMF) syndrome because of the low risk of graft-versus-host disease (GVHD) and the absence of risk to the donor. We analyzed outcomes of 117 patients with inherited or acquired BMF syndrome who received CBT from a related HLA-identical donor in European Society for Blood and Marrow Transplantation centers between 1988 and 2014. Ninety-seven patients had inherited and 20 patients acquired BMF syndrome. Eighty-two patients received a single cord blood (CB) unit, whereas 35 patients received a combination of CB and bone marrow cells from the same donor. Median age at CBT was 6.7 years, and median follow-up was 86.7 months. The cumulative incidence function (CIF) of neutrophil recovery was 88.8% (95% CI, 83.1% to 94.9%), 100-day CIF of grades II to IV acute GVHD was 15.2%, and 7-year CIF of chronic GVHD was 14.5%. Overall survival at 7 years was 87.9% (95% CI, 80.8% to 92.6%), 89% for inherited and 81% for acquired BMF syndromes (P=.66). Results of this study are consistent with outcomes of bone marrow transplantation shown by previous series in the same setting and indicate that in pediatric patients with BMF syndrome, CBT from an HLA-identical sibling donor is associated with excellent long-term outcomes and that collection of CB unit at birth of a new sibling is strongly recommended. (C) 2017 American Society for Blood and Marrow Transplantation.
Subject: Bone marrow failure
Cord blood transplantation
Severe aplastic anemia
STEM-CELL TRANSPLANTATION
DIAMOND-BLACKFAN-ANEMIA
VERSUS-HOST-DISEASE
FANCONI-ANEMIA
UNRELATED DONORS
PERIPHERAL-BLOOD
CHRONIC GRAFT
CHRONIC GVHD
CYCLOPHOSPHAMIDE
FLUDARABINE
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S1083879117306262_main.pdf 468.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record