Serotonin transporter density in binge eating disorder and pathological gambling : A PET study with [C-11]MADAM

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Majuri , J , Joutsa , J , Johansson , J , Voon , V , Parkkola , R , Alho , H , Arponen , E & Kaasinen , V 2017 , ' Serotonin transporter density in binge eating disorder and pathological gambling : A PET study with [C-11]MADAM ' , European Neuropsychopharmacology , vol. 27 , no. 12 , pp. 1281-1288 .

Title: Serotonin transporter density in binge eating disorder and pathological gambling : A PET study with [C-11]MADAM
Author: Majuri, Joonas; Joutsa, Juho; Johansson, Jarkko; Voon, Valerie; Parkkola, Riitta; Alho, Hannu; Arponen, Eveliina; Kaasinen, Valtteri
Contributor organization: Clinicum
Department of Medicine
HUS Internal Medicine and Rehabilitation
Date: 2017-12
Language: eng
Number of pages: 8
Belongs to series: European Neuropsychopharmacology
ISSN: 0924-977X
Abstract: Behavioral addictions, such as pathological gambling (PG) and binge eating disorder (BED), appear to be associated with specific changes in brain dopamine and opioid function, but the role of other neurotransmitter systems is less clear. Given the crucial role of serotonin in a number of psychiatric disorders, we aimed to compare brain serotonergic function among individuals with BED, PG and healthy controls. Seven BED patients, 13 PG patients and 16 healthy controls were scanned with high-resolution positron emission tomography (PET) using the serotonin transporter (SERT) tracer [C-11]MADAM. Both region-of-interest and voxel-wise whole brain analyses were performed. Patients with BED showed increased SERT binding in the parieto-occipital cortical regions compared to both PG and healthy controls, with parallel decreases in binding in the nucleus accumbens, inferior temporal gyrus and lateral orbitofrontal cortex. No differences between PG patients and controls were observed. None of the subjects were on SSRI medications at the time of imaging, and there were no differences in the level of depression between PG and BED patients. The results highlight differences in brain SERT binding between individuals with BED and PG and provide further evidence of different neurobiological underpinnings in behavioral addictions that are unrelated to the co-existing mood disorder. The results aid in the conceptualization of behavioral addictions by characterizing the underlying serotonin changes and provide a framework for additional studies to examine syndrome-specific pharmaceutical treatments. (C) 2017 Elsevier B.V. and ECNP. All rights reserved.
Subject: [C-11]MADAM
Binge eating
Pathological gambling
Positron emission tomography
Serotonin transporter
3112 Neurosciences
3124 Neurology and psychiatry
317 Pharmacy
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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