Early life origin of type 1 diabetes

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Knip , M , Luopajarvi , K & Harkonen , T 2017 , ' Early life origin of type 1 diabetes ' , Seminars in Immunopathology , vol. 39 , no. 6 , pp. 653-667 . https://doi.org/10.1007/s00281-017-0665-6

Title: Early life origin of type 1 diabetes
Author: Knip, Mikael; Luopajarvi, Kristiina; Harkonen, Taina
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-11
Language: eng
Number of pages: 15
Belongs to series: Seminars in Immunopathology
ISSN: 1863-2297
URI: http://hdl.handle.net/10138/298164
Abstract: Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World War II in parallel with a series of other immune-mediated diseases. T1D results from gene-environmental interactions. The appearance of disease-associated autoantibodies into the peripheral circulation is the first detectable sign of the initiation of the disease process leading to clinical T1D. The first autoantibodies may appear already before the age of 6 months and the seroconversion rate peaks during the second year of life. This implies that exogenous factors involved in the pathogenesis of T1D must be operative in early life, some of them most likely already during pregnancy. Here, we discuss putative endogenous factors that may contribute to the development of T1D during fetal and early postnatal life. Many environmental factors operative in early life have been implicated in the pathogenesis of T1D, but relatively few have been firmly confirmed.
Subject: Type 1 diabetes
Environmental determinants
Conception
Fetal life
Postnatal life
Omics
BETA-CELL AUTOIMMUNITY
HLA-CONFERRED SUSCEPTIBILITY
PRECEDES ISLET AUTOIMMUNITY
COD-LIVER OIL
INCREASED RISK
GENERAL-POPULATION
YOUNG-CHILDREN
ENTEROVIRUS INFECTION
CONGENITAL-RUBELLA
FINNISH CHILDREN
3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
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