Quantitative MRI of Human Cartilage In Vivo : Relationships with Arthroscopic Indentation Stiffness and Defect Severity

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Svard , T , Lakovaara , M , Pakarinen , H , Haapea , M , Kiviranta , I , Lammentausta , E , Jurvelin , J , Tervonen , O , Ojala , R & Nieminen , M 2018 , ' Quantitative MRI of Human Cartilage In Vivo : Relationships with Arthroscopic Indentation Stiffness and Defect Severity ' , Cartilage , vol. 9 , no. 1 , pp. 46-54 . https://doi.org/10.1177/1947603516684592

Title: Quantitative MRI of Human Cartilage In Vivo : Relationships with Arthroscopic Indentation Stiffness and Defect Severity
Author: Svard, Tuomas; Lakovaara, Martti; Pakarinen, Harri; Haapea, Marianne; Kiviranta, Ilkka; Lammentausta, Eveliina; Jurvelin, Jukka; Tervonen, Osmo; Ojala, Risto; Nieminen, Miika
Contributor: University of Helsinki, Clinicum
Date: 2018-01
Language: eng
Number of pages: 9
Belongs to series: Cartilage
ISSN: 1947-6035
URI: http://hdl.handle.net/10138/298174
Abstract: Objective. To investigate the association of cartilage defect severity, as determined by the International Cartilage Repair Society (ICRS) grading with indentation stiffness and T2 relaxation time of magnetic resonance imaging (MRI), a biomarker for the integrity of articular cartilage. Design. Twenty-one patients scheduled for arthroscopic were included in the study. Prior to arthroscopy, subjects underwent quantitative MRI of articular cartilage, namely T2 relaxation time mapping at 1.5 T. Within 2 months, subjects underwent arthroscopy, which also included ICRS grading and measurement of arthroscopic indentation stiffness. Arthroscopic evaluations and T2 mapping at anterior, central, and posterior medial and lateral femoral condyles were correlated using a colocalization scheme. Differences in Young's modulus, as derived by indentation tests, and T2 times between ICRS grades were analyzed using Mann-Whitney's U or Kruskal-Wallis H tests. The correlation between modulus and T2 times was analyzed using Spearman's rank correlation coefficients. Results. Modulus and T2 showed significant topographical variation. In the anterior region of interest (ROI) on the medial condyle the modulus showed a negative association with ICRS grade (P = 0.040) and the T2 times were longer in ICRS grade 2 compared with grades 0 and 1 (P = 0.047). Similar, but nonsignificant associations were found in the central ROI on the medial condyle. No significant correlations were observed between the indentation modulus and T2 times. Conclusions. Cartilage degeneration is identified both with mechanical indentation and T2 mapping in MRI. However, in this study, indentation stiffness and T2 relaxation time in vivo, were not associated.
Subject: articular cartilage
osteoarthritis
MRI
T2 relaxation
arthroscopy
indentation
HUMAN ARTICULAR-CARTILAGE
T2 RELAXATION-TIME
KNEE OSTEOARTHRITIS
BIOMECHANICAL PROPERTIES
OARSI RECOMMENDATIONS
DEGENERATION
MANAGEMENT
HIP
RELIABILITY
DIAGNOSTICS
3126 Surgery, anesthesiology, intensive care, radiology
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