Key role of local acetaldehyde in upper GI tract carcinogenesis
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Salaspuro , M 2017 , ' Key role of local acetaldehyde in upper GI tract carcinogenesis ' , Best Practice & Research: Clinical Gastroenterology , vol. 31 , no. 5 , pp. 491-499 . https://doi.org/10.1016/j.bpg.2017.09.016
| Title: | Key role of local acetaldehyde in upper GI tract carcinogenesis |
| Author: | Salaspuro, Mikko |
| Contributor organization: | Clinicum University of Helsinki HUS Internal Medicine and Rehabilitation |
| Date: | 2017-10 |
| Language: | eng |
| Number of pages: | 9 |
| Belongs to series: | Best Practice & Research: Clinical Gastroenterology |
| ISSN: | 1521-6918 |
| DOI: | https://doi.org/10.1016/j.bpg.2017.09.016 |
| URI: | http://hdl.handle.net/10138/298233 |
| Abstract: | Ethanol is neither genotoxic nor mutagenic. Its first metabolite acetaldehyde, however, is a powerful local carcinogen. Point mutation in ALDH2 gene proves the causal relationship between acetaldehyde and upper digestive tract cancer in humans. Salivary acetaldehyde concentration and exposure time are the two major and quantifiable factors regulating the degree of local acetaldehyde exposure in the ideal target organ, oropharynx. Instant microbial acetaldehyde formation from alcohol represents >70% of total ethanol associated acetaldehyde exposure in the mouth. In the oropharynx and achlorhydric stomach acetaldehyde is not metabolized to safe products, instead in the presence of alcohol it accumulates in saliva and gastric juice in mutagenic concentrations. A common denominator in alcohol, tobacco and food associated upper digestive tract carcinogenesis is acetaldehyde. Epidemiological studies on upper GI tract cancer are biased, since they miss information on acetaldehyde exposure derived from alcohol and acetaldehyde present in 'non-alcoholic' beverages and food. (C) 2017 Published by Elsevier Ltd. |
| Subject: |
Acetaldehyde
Alcohol ALDH2 Cancer Cancer risk assessment Ethanol Fermented food L-cysteine Mouth Oesophagus Oropharynx Pharynx Stomach Tobacco ALDEHYDE DEHYDROGENASE 2 CHRONIC ATROPHIC GASTRITIS UPPER AERODIGESTIVE TRACT SQUAMOUS-CELL CARCINOMA ORAL-CAVITY CANCER SALIVARY ACETALDEHYDE ALCOHOL-DEHYDROGENASE ESOPHAGEAL CANCER HELICOBACTER-PYLORI HEAVY DRINKERS Acetaldehyde Alcohol ALDH2 Cancer Cancer risk assessment Ethanol Fermented food L-cysteine Mouth Oesophagus Oropharynx Pharynx Stomach Tobacco 3111 Biomedicine |
| Peer reviewed: | Yes |
| Usage restriction: | openAccess |
| Self-archived version: | publishedVersion |
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