Key role of local acetaldehyde in upper GI tract carcinogenesis

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http://hdl.handle.net/10138/298233

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Salaspuro , M 2017 , ' Key role of local acetaldehyde in upper GI tract carcinogenesis ' , Best Practice & Research: Clinical Gastroenterology , vol. 31 , no. 5 , pp. 491-499 . https://doi.org/10.1016/j.bpg.2017.09.016

Title: Key role of local acetaldehyde in upper GI tract carcinogenesis
Author: Salaspuro, Mikko
Contributor: University of Helsinki, Clinicum
Date: 2017-10
Language: eng
Number of pages: 9
Belongs to series: Best Practice & Research: Clinical Gastroenterology
ISSN: 1521-6918
URI: http://hdl.handle.net/10138/298233
Abstract: Ethanol is neither genotoxic nor mutagenic. Its first metabolite acetaldehyde, however, is a powerful local carcinogen. Point mutation in ALDH2 gene proves the causal relationship between acetaldehyde and upper digestive tract cancer in humans. Salivary acetaldehyde concentration and exposure time are the two major and quantifiable factors regulating the degree of local acetaldehyde exposure in the ideal target organ, oropharynx. Instant microbial acetaldehyde formation from alcohol represents >70% of total ethanol associated acetaldehyde exposure in the mouth. In the oropharynx and achlorhydric stomach acetaldehyde is not metabolized to safe products, instead in the presence of alcohol it accumulates in saliva and gastric juice in mutagenic concentrations. A common denominator in alcohol, tobacco and food associated upper digestive tract carcinogenesis is acetaldehyde. Epidemiological studies on upper GI tract cancer are biased, since they miss information on acetaldehyde exposure derived from alcohol and acetaldehyde present in 'non-alcoholic' beverages and food. (C) 2017 Published by Elsevier Ltd.
Subject: Acetaldehyde
Alcohol
ALDH2
Cancer
Cancer risk assessment
Ethanol
Fermented food
L-cysteine
Mouth
Oesophagus
Oropharynx
Pharynx
Stomach
Tobacco
ALDEHYDE DEHYDROGENASE 2
CHRONIC ATROPHIC GASTRITIS
UPPER AERODIGESTIVE TRACT
SQUAMOUS-CELL CARCINOMA
ORAL-CAVITY CANCER
SALIVARY ACETALDEHYDE
ALCOHOL-DEHYDROGENASE
ESOPHAGEAL CANCER
HELICOBACTER-PYLORI
HEAVY DRINKERS
Acetaldehyde
Alcohol
ALDH2
Cancer
Cancer risk assessment
Ethanol
Fermented food
L-cysteine
Mouth
Oesophagus
Oropharynx
Pharynx
Stomach
Tobacco
3111 Biomedicine
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