Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)

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Hjort , R , Alfredsson , L , Andersson , T , Carlsson , P -O , Grill , V , Groop , L , Martinell , M , Rasouli , B , Storm , P , Tuomi , T & Carlsson , S 2017 , ' Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA) ' , Diabetes & metabolism , vol. 43 , no. 6 , pp. 536-542 . https://doi.org/10.1016/j.diabet.2017.05.010

Title: Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA)
Author: Hjort, R.; Alfredsson, L.; Andersson, T.; Carlsson, P. -O.; Grill, V.; Groop, L.; Martinell, M.; Rasouli, B.; Storm, P.; Tuomi, T.; Carlsson, S.
Contributor: University of Helsinki, HUS Abdominal Center
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-12
Language: eng
Number of pages: 7
Belongs to series: Diabetes & metabolism
ISSN: 1262-3636
URI: http://hdl.handle.net/10138/298240
Abstract: Background. - A family history of diabetes (FHD) is a strong predictor of diabetes risk, yet has rarely been investigated in latent autoimmune diabetes in adults (LADA). This study therefore investigated the risk of LADA and type 2 diabetes (T2D) in relation to FHD, taking into account the type of diabetes in relatives. Methods. - Data from a population-based study were used, including incident cases of LADA [glutamic acid decarboxylase antibody (GADA)-positive, n = 378] and T2D (GADA-negative, n = 1199), and their matched controls (n = 1484). First-degree relatives with disease onset at age <40 years and taking insulin treatment were classified as type 1 diabetes (T1D) or, if otherwise, as T2D. Odds ratios (ORs) were adjusted for age, gender, BMI, education and smoking. Cases were genotyped for high- and low-risk HLA genotypes. Results. - Both FHD-T1D (OR: 5.8; 95% CI: 3.2-10.3) and FHD-T2D (OR: 1.9; 95% CI: 1.5-2.5) were associated with an increased risk of LADA, whereas the risk of T2D was associated with FHD-T2D (OR: 2.7; 95% CI: 2.2-3.3), but not FHD-Tl D. In LADA patients, FHD-T1D vs FHD-T2D was associated with higher GADA but lower C-peptide levels, lower prevalence of low-risk HLA genotypes (5.0% vs 28.6%, respectively; P = 0.038) and a tendency for higher prevalence of high-risk genotypes (90.0% vs 69.1%, respectively; P = 0.0576). Conclusion. - The risk of LADA is substantially increased with FHD-Tl D but also, albeit significantly less so, with FHD-T2D. This supports the idea of LADA as a mix of both T1D and T2D, but suggests that the genes related to T1D have greater impact. LADA patients with FHD-Tl D had more T1D-like features, emphasizing the heterogeneity of LADA. (C) 2017 Elsevier Masson SAS. All rights reserved.
Subject: Autoimmune diabetes
Case-control study
Family history of diabetes
Heredity
Latent autoimmune diabetes in adults
Type 2 diabetes
HLA-DR
GENETICS
AUTOANTIBODIES
POPULATION
PHENOTYPE
VARIANTS
3121 General medicine, internal medicine and other clinical medicine
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