Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients

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dc.contributor.author Nilsson, Anna
dc.contributor.author Tervahartiala, Taina
dc.contributor.author Lennebratt, David
dc.contributor.author Lannergård, Anders
dc.contributor.author Sorsa, Timo
dc.contributor.author Rautelin, Hilpi
dc.date.accessioned 2019-01-24T08:55:01Z
dc.date.available 2019-01-24T08:55:01Z
dc.date.issued 2018-12
dc.identifier.citation Nilsson , A , Tervahartiala , T , Lennebratt , D , Lannergård , A , Sorsa , T & Rautelin , H 2018 , ' Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients ' , Diagnostics , vol. 8 , no. 4 , 82 . https://doi.org/10.3390/diagnostics8040082
dc.identifier.other PURE: 121569893
dc.identifier.other PURE UUID: b92b2603-bbd4-4e4d-861f-1fedd1bd7068
dc.identifier.other WOS: 000455064800015
dc.identifier.uri http://hdl.handle.net/10138/298291
dc.description.abstract Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several tissue destructive diseases, including infections. We measured here serum concentrations of MMP-8 and MMP-9 together with their regulators myeloperoxidase (MPO), human neutrophil elastase (HNE), and tissue inhibitor of metalloproteinases (TIMP)-1 in 80 Campylobacter and 25 Salmonella patients as well as in 27 healthy controls. Paired serum samples were available for 73 and 23 patients, respectively. When the initial serum samples were compared to those from controls, both Campylobacter and Salmonella patients showed elevated concentrations of all biomarkers tested (p 0.037). In the follow-up samples, collected about 25 days afterwards, MMP-8 levels of Campylobacter patients had already turned to normal but all the other biomarkers still showed elevated, although from the initial levels significantly dropped, levels. For the follow-up samples of Salmonella patients, only MMP-9 and MPO levels were at a significantly higher level than in controls. It remains to be studied if the systematically enhanced neutrophil-derived proteolytic and oxidative stress, induced by Campylobacter infection as shown here and persisting for several weeks, is important for the development of late sequelae. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof Diagnostics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Campylobacter
dc.subject Salmonella
dc.subject enteritis
dc.subject matrix metalloproteinase (MMP)-8
dc.subject matrix metalloproteinase (MMP)-9
dc.subject tissue inhibitor of metalloproteinases (TIMP)-1
dc.subject myeloperoxidase
dc.subject human neutrophil elastase
dc.subject JEJUNI
dc.subject INFECTION
dc.subject BACTEREMIA
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization HUS Head and Neck Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/diagnostics8040082
dc.relation.issn 2075-4418
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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