EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer

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Birkman , E-M , Avoranta , T , Algars , A , Korkeila , E , Lintunen , M , Lahtinen , L , Kuopio , T , Ristamäki , R , Carpen , O & Sundström , J 2018 , ' EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer ' , Human Pathology , vol. 82 , pp. 163-171 . https://doi.org/10.1016/j.humpath.2018.07.028

Title: EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer
Author: Birkman, Eva-Maria; Avoranta, Tuulia; Algars, Annika; Korkeila, Eija; Lintunen, Minnamaija; Lahtinen, Laura; Kuopio, Teijo; Ristamäki, Raija; Carpen, Olli; Sundström, Jari
Contributor: University of Helsinki, HUSLAB
Date: 2018-12
Language: eng
Number of pages: 9
Belongs to series: Human Pathology
ISSN: 0046-8177
URI: http://hdl.handle.net/10138/298306
Abstract: Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favorable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited and comparative data regarding the EGFR GCN in primary colorectal cancer tumors and corresponding metastases or the effect of anti-EGFR antibody treatment on EGFR GCN in recurrent disease. In addition, little is known about the potential EGFR GCN changes during anti-EGFR therapy in comparison with other treatment regimens. EGFR GCN was analyzed by EGFR immunohistochemistry-guided silver in situ hybridization in primary and corresponding recurrent local or metastatic tumors from 80 colorectal cancer patients. GCN levels were compared between KRAS wild-type patients having received antiEGFR therapy and patients having received other forms of treatment after primary surgery. The EGFR GCN decrease between primary and recurrent tumors was more pronounced among the anti EGFR-treated patients than among patients not treated with anti-EGFR therapy (P=.047). None of the patients experiencing an EGFR GCN increase of at least 1.0 between the primary and recurrent tumors were treated with antiEGFR antibodies. When including only patients with distant metastases, an EGFR GCN decrease of at least 1.0 was more common among the anti EGFR-treated patients than among patients not treated with anti-EGFR therapy (P=.028). Our results suggest that anti-EGFR antibody treatment is associated with EGFR GCN decrease between the primary and recurrent colorectal adenocarcinomas, whereas no GCN change is observed among patients receiving other forms of treatment after primary surgery. (C) 2018 The Authors. Published by Elsevier Inc.
Subject: Colorectal cancer
Epidermal growth factor receptor
Gene copy number
Silver in situ hybridization
Monoclonal antibody
ACQUIRED-RESISTANCE
CETUXIMAB THERAPY
PREDICTS RESPONSE
RAS MUTATIONS
WILD-TYPE
KRAS
HETEROGENEITY
METAANALYSIS
BLOCKADE
BENEFIT
3111 Biomedicine
3122 Cancers
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