Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality

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Fernandez , C , Rysä , J , Almgren , P , Nilsson , J , Engström , G , Orho-Melander , M , Ruskoaho , H & Melander , O 2018 , ' Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality ' , Journal of Internal Medicine , vol. 284 , no. 4 , pp. 377-387 .

Title: Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality
Author: Fernandez, C.; Rysä, J.; Almgren, P.; Nilsson, J.; Engström, G.; Orho-Melander, M.; Ruskoaho, H.; Melander, O.
Contributor organization: Division of Pharmacology and Pharmacotherapy
Drug Research Program
Regenerative pharmacology group
Date: 2018-10
Language: eng
Number of pages: 11
Belongs to series: Journal of Internal Medicine
ISSN: 0954-6820
Abstract: Background. Diabetes mellitus is linked to premature mortality of virtually all causes. Furin is a proprotein convertase broadly involved in the maintenance of cellular homeostasis; however, little is known about its role in the development of diabetes mellitus and risk of premature mortality. Objectives. To test if fasting plasma concentration of furin is associated with the development of diabetes mellitus and mortality. Methods. Overnight fasted plasma furin levels were measured at baseline examination in 4678 individuals from the population-based prospective Malmo Diet and Cancer Study. We studied the relation of plasma furin levels with metabolic and hemodynamic traits. We used multivariable Cox proportional hazards models to investigate the association between baseline plasma furin levels and incidence of diabetes mellitus and mortality during 21.3-21.7 years follow-up. Results. An association was observed between quartiles of furin concentration at baseline and body mass index, blood pressure and plasma concentration of glucose, insulin, LDL and HDL cholesterol (vertical bar 0.11 vertical bar Conclusion. Individuals with high plasma furin concentration have a pronounced dysmetabolic phenotype and elevated risk of diabetes mellitus and premature mortality.
Subject: diabetes mellitus
population-based cohort
risk prediction
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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