Wester , N , Etula , J , Lilius , T , Sainio , S , Laurila , T & Koskinen , J 2018 , ' Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes ' , Electrochemistry Communications , vol. 86 , pp. 166-170 . https://doi.org/10.1016/j.elecom.2017.12.014
Title: | Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes |
Author: | Wester, Niklas; Etula, Jarkko; Lilius, Tuomas; Sainio, Sami; Laurila, Tomi; Koskinen, Jari |
Contributor organization: | HUSLAB Medicum Department of Pharmacology Department of Clinical Pharmacology Clinicum University of Helsinki |
Date: | 2018-01 |
Language: | eng |
Number of pages: | 5 |
Belongs to series: | Electrochemistry Communications |
ISSN: | 1388-2481 |
DOI: | https://doi.org/10.1016/j.elecom.2017.12.014 |
URI: | http://hdl.handle.net/10138/298559 |
Abstract: | We investigated the effect of anodic treatment of titanium/tetrahedral amorphous carbon electrodes on the electrochemical detection of morphine and paracetamol. The anodic treatment caused both oxidation of the carbon and, more importantly, exposure and oxidation of the underlying Ti layer. This treatment anodically shifted the oxidation potential of paracetamol while that of morphine remained unaffected. The resulting electrode also showed better selectivity than a ta-C electrode without Ti. After anodic treatment at 2.5 V, selective detection of morphine with a physiologically meaningful detection limit of 9.8 nM and a linear range of 0.1-10 mu M was obtained in the presence of 100 mu M paracetamol. |
Subject: |
Morphine
Paracetamol Titanium Tetrahedral amorphous carbon Voltammetry THIN-FILM ELECTRODES ELECTROCHEMICAL PROPERTIES OXYGEN FUNCTIONALITIES ACETAMINOPHEN METABOLITES DOPAMINE BEHAVIOR 3111 Biomedicine 317 Pharmacy |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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