Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes

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http://hdl.handle.net/10138/298559

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Wester , N , Etula , J , Lilius , T , Sainio , S , Laurila , T & Koskinen , J 2018 , ' Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes ' , Electrochemistry Communications , vol. 86 , pp. 166-170 . https://doi.org/10.1016/j.elecom.2017.12.014

Title: Selective detection of morphine in the presence of paracetamol with anodically pretreated dual layer Ti/tetrahedral amorphous carbon electrodes
Author: Wester, Niklas; Etula, Jarkko; Lilius, Tuomas; Sainio, Sami; Laurila, Tomi; Koskinen, Jari
Contributor: University of Helsinki, HUSLAB
Date: 2018-01
Language: eng
Number of pages: 5
Belongs to series: Electrochemistry Communications
ISSN: 1388-2481
URI: http://hdl.handle.net/10138/298559
Abstract: We investigated the effect of anodic treatment of titanium/tetrahedral amorphous carbon electrodes on the electrochemical detection of morphine and paracetamol. The anodic treatment caused both oxidation of the carbon and, more importantly, exposure and oxidation of the underlying Ti layer. This treatment anodically shifted the oxidation potential of paracetamol while that of morphine remained unaffected. The resulting electrode also showed better selectivity than a ta-C electrode without Ti. After anodic treatment at 2.5 V, selective detection of morphine with a physiologically meaningful detection limit of 9.8 nM and a linear range of 0.1-10 mu M was obtained in the presence of 100 mu M paracetamol.
Subject: Morphine
Paracetamol
Titanium
Tetrahedral amorphous carbon
Voltammetry
THIN-FILM ELECTRODES
ELECTROCHEMICAL PROPERTIES
OXYGEN FUNCTIONALITIES
ACETAMINOPHEN
METABOLITES
DOPAMINE
BEHAVIOR
3111 Biomedicine
317 Pharmacy
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