Leisure-time physical activity and DNA methylation agea twin study

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http://hdl.handle.net/10138/298567

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Sillanpaa , E , Ollikainen , M , Kaprio , J , Wang , X , Leskinen , T , Kujala , U M & Tormakangas , T 2019 , ' Leisure-time physical activity and DNA methylation agea twin study ' , Clinical epigenetics , vol. 11 , 12 . https://doi.org/10.1186/s13148-019-0613-5

Title: Leisure-time physical activity and DNA methylation agea twin study
Author: Sillanpaa, Elina; Ollikainen, Miina; Kaprio, Jaakko; Wang, Xiaoling; Leskinen, Tuija; Kujala, Urho M.; Tormakangas, Timo
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-01-19
Language: eng
Number of pages: 8
Belongs to series: Clinical epigenetics
ISSN: 1868-7083
URI: http://hdl.handle.net/10138/298567
Abstract: BackgroundEpigenetic clocks may increase our understanding on human aging and how genetic and environmental factors regulate an individual aging process. One of the most promising clocks is Horvath's DNA methylation (DNAm) age. Age acceleration, i.e., discrepancy between DNAm age and chronological age, tells us whether the person is biologically young or old compared to his/her chronological age. Several environmental and lifestyle factors have been shown to affect life span. We investigated genetic and environmental predictors of DNAm age in young and older monozygotic (MZ) and dizygotic (DZ) twins with a focus on leisure time physical activity.ResultsQuantitative genetic modeling revealed that the relative contribution of non-shared environmental factors was larger among older compared with younger twin pairs [47% (95% CI 35, 63) vs. 26% (95% CI: 19, 35), p
Subject: Epigenetic clock
Methylation
Twin design
Physical activity
Quantitative genetics
EPIGENETIC CLOCK
PAIRS DISCORDANT
HEALTH-BENEFITS
COHORT
LIFE
3122 Cancers
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