Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders

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Slack , J , Albert , M H , Balashov , D , Belohradsky , B H , Bertaina , A , Bleesing , J , Booth , C , Buechner , J , Buckley , R H , Ouachee-Chardin , M , Deripapa , E , Drabko , K , Eapen , M , Feuchtinger , T , Finocchi , A , Gaspar , H B , Ghosh , S , Gillio , A , Gonzalez-Granado , L I , Grunebaum , E , Gungor , T , Heilmann , C , Helminen , M , Higuchi , K , Imai , K , Kalwak , K , Kanazawa , N , Karasu , G , Kucuk , Z Y , Laberko , A , Lange , A , Mahlaoui , N , Meisel , R , Moshous , D , Muramatsu , H , Parikh , S , Pasic , S , Schmid , I , Schuetz , C , Schulz , A , Schultz , K R , Shaw , P J , Slatter , M A , Sykora , K-W , Tamura , S , Taskinen , M , Wawer , A , Wolska-Kusnierz , B , Cowan , M J , Fischer , A , European Soc Blood Marrow , European Soc Immunodeficiencies , Stem Cell Transplant , Ctr Int Blood Marrow & Primary Immunodeficiency Treatment 2018 , ' Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders ' , Journal of Allergy and Clinical Immunology , vol. 141 , no. 1 , pp. 322-+ . https://doi.org/10.1016/j.jaci.2017.02.036

Title: Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders
Author: Slack, James; Albert, Michael H.; Balashov, Dmitry; Belohradsky, Bernd H.; Bertaina, Alice; Bleesing, Jack; Booth, Claire; Buechner, Jochen; Buckley, Rebecca H.; Ouachee-Chardin, Marie; Deripapa, Elena; Drabko, Katarzyna; Eapen, Mary; Feuchtinger, Tobias; Finocchi, Andrea; Gaspar, H. Bobby; Ghosh, Sujal; Gillio, Alfred; Gonzalez-Granado, Luis I.; Grunebaum, Eyal; Gungor, Tayfun; Heilmann, Carsten; Helminen, Merja; Higuchi, Kohei; Imai, Kohsuke; Kalwak, Krzysztof; Kanazawa, Nubuo; Karasu, Gulsun; Kucuk, Zeynep Y.; Laberko, Alexandra; Lange, Andrzej; Mahlaoui, Nizar; Meisel, Roland; Moshous, D.; Muramatsu, Hideki; Parikh, Suhag; Pasic, Srdjan; Schmid, Irene; Schuetz, Catharina; Schulz, Ansgar; Schultz, Kirk R.; Shaw, Peter J.; Slatter, Mary A.; Sykora, Karl-Walter; Tamura, Shinobu; Taskinen, Mervi; Wawer, Angela; Wolska-Kusnierz, Beata; Cowan, Morton J.; Fischer, Alain; European Soc Blood Marrow; European Soc Immunodeficiencies; Stem Cell Transplant; Ctr Int Blood Marrow; Primary Immunodeficiency Treatment
Contributor organization: Lastentautien yksikkö
Children's Hospital
HUS Children and Adolescents
HUS Comprehensive Cancer Center
Date: 2018-01
Language: eng
Number of pages: 17
Belongs to series: Journal of Allergy and Clinical Immunology
ISSN: 0091-6749
DOI: https://doi.org/10.1016/j.jaci.2017.02.036
URI: http://hdl.handle.net/10138/298620
Abstract: Background: Rare DNA breakage repair disorders predispose to infection and lymphoreticular malignancies. Hematopoietic cell transplantation (HCT) is curative, but coadministered chemotherapy or radiotherapy is damaging because of systemic radiosensitivity. We collected HCT outcome data for Nijmegen breakage syndrome, DNA ligase IV deficiency, Cernunnos-XRCC4-like factor (Cernunnos-XLF) deficiency, and ataxia-telangiectasia (AT). Methods: Data from 38 centers worldwide, including indication, donor, conditioning regimen, graft-versus-host disease, and outcome, were analyzed. Conditioning was classified as myeloablative conditioning (MAC) if it contained radiotherapy or alkylators and reduced-intensity conditioning (RIC) if no alkylators and/or 150 mg/m(2) fludarabine or less and 40 mg/kg cyclophosphamide or less were used. Results: Fifty-five new, 14 updated, and 18 previously published patients were analyzed. Median age at HCT was 48 months (range, 1.5-552 months). Twenty-nine patients underwent transplantation for infection, 21 had malignancy, 13 had bone marrow failure, 13 received pre-emptive transplantation, 5 had multiple indications, and 6 had no information. Twenty-two received MAC, 59 received RIC, and 4 were infused; information was unavailable for 2 patients. Seventy-three of 77 patients with DNA ligase IV deficiency, Cernunnos-XLF deficiency, or Nijmegen breakage syndrome received conditioning. Survival was 53 (69%) of 77 and was worse for those receiving MAC than for those receiving RIC (P=.006). Most deaths occurred early after transplantation, suggesting poor tolerance of conditioning. Survival in patients with AT was 25%. Forty-one (49%) of 83 patients experienced acute GvHD, which was less frequent in those receiving RIC compared with those receiving MAC (26/56 [46%] vs 12/21 [57%], P=.45). Median follow-up was 35 months (range, 2-168 months). No secondary malignancies were reported during 15 years of follow-up. Growth and developmental delay remained after HCT; immune-mediated complications resolved. Conclusion: RIC HCT resolves DNA repair disorder associated immunodeficiency. Long-term follow-up is required for secondary malignancy surveillance. Routine HCT for AT is not recommended.
Subject: Ataxia-telangiectasia
Cernunnos-XLF deficiency
DNA repair disorders
DNA ligase IV deficiency
hematopoietic stem cell transplantation
Nijmegen breakage syndrome
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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