Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland

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http://hdl.handle.net/10138/298690

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Strausz , S , Havulinna , A S , Tuomi , T , Bachour , A , Groop , L , Mäkitie , A , Koskinen , S , Salomaa , V , Palotie , A , Ripatti , S & Palotie , T 2018 , ' Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland ' , BMJ Open , vol. 8 , no. 10 , 022752 . https://doi.org/10.1136/bmjopen-2018-022752

Julkaisun nimi: Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland
Tekijä: Strausz, Satu; Havulinna, Aki S.; Tuomi, Tiinamaija; Bachour, Adel; Groop, Leif; Mäkitie, Antti; Koskinen, Seppo; Salomaa, Veikko; Palotie, Aarno; Ripatti, Samuli; Palotie, Tuula
Muu tekijä: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Clinicum
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Department of Oral and Maxillofacial Diseases
Päiväys: 2018-10
Kieli: eng
Sivumäärä: 8
Kuuluu julkaisusarjaan: BMJ Open
ISSN: 2044-6055
URI: http://hdl.handle.net/10138/298690
Tiivistelmä: Objective To evaluate if obstructive sleep apnoea (OSA) modifies the risk of coronary heart disease, type 2 diabetes (T2D) and diabetic complications in a gender-specific fashion. Design and setting A longitudinal population-based study with up to 25-year follow-up data on 36 963 individuals (>500 000 person years) from three population-based cohorts: the FINRISK study, the Health 2000 Cohort Study and the Botnia Study. Main outcome measures Incident coronary heart disease, diabetic kidney disease, T2D and all-cause mortality from the Finnish National Hospital Discharge Register and the Finnish National Causes-of-Death Register. Results After adjustments for age, sex, region, high-density lipoprotein (HDL) and total cholesterol, current cigarette smoking, body mass index, hypertension, T2D baseline and family history of stroke or myocardial infarction, OSA increased the risk for coronary heart disease (HR=1.36, p=0.0014, 95% CI 1.12 to 1.64), particularly in women (HR=2.01, 95% CI 1.31 to 3.07, p=0.0012). T2D clustered with OSA independently of obesity (HR=1.48, 95% CI 1.26 to 1.73, p=9.11x10(-7)). The risk of diabetic kidney disease increased 1.75-fold in patients with OSA (95% CI 1.13 to 2.71, p=0.013). OSA increased the risk for coronary heart disease similarly among patients with T2D and in general population (HR=1.36). All-cause mortality was increased by OSA in diabetic individuals (HR=1.35, 95% CI 1.06 to 1.71, p=0.016). Conclusion OSA is an independent risk factor for coronary heart disease, T2D and diabetic kidney disease. This effect is more pronounced even in women, who until now have received less attention in diagnosis and treatment of OSA than men.
Avainsanat: MIDDLE-AGED MEN
NEPHROPATHY
ASSOCIATION
PREVALENCE
3121 General medicine, internal medicine and other clinical medicine
3125 Otorhinolaryngology, ophthalmology
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