Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland

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dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Centre of Excellence in Complex Disease Genetics en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Centre of Excellence in Complex Disease Genetics en
dc.contributor University of Helsinki, Department of Ophthalmology and Otorhinolaryngology en
dc.contributor University of Helsinki, Centre of Excellence in Complex Disease Genetics en
dc.contributor University of Helsinki, Centre of Excellence in Complex Disease Genetics en
dc.contributor University of Helsinki, Department of Oral and Maxillofacial Diseases en
dc.contributor.author Strausz, Satu
dc.contributor.author Havulinna, Aki S.
dc.contributor.author Tuomi, Tiinamaija
dc.contributor.author Bachour, Adel
dc.contributor.author Groop, Leif
dc.contributor.author Mäkitie, Antti
dc.contributor.author Koskinen, Seppo
dc.contributor.author Salomaa, Veikko
dc.contributor.author Palotie, Aarno
dc.contributor.author Ripatti, Samuli
dc.contributor.author Palotie, Tuula
dc.date.accessioned 2019-02-05T13:32:03Z
dc.date.available 2019-02-05T13:32:03Z
dc.date.issued 2018-10
dc.identifier.citation Strausz , S , Havulinna , A S , Tuomi , T , Bachour , A , Groop , L , Mäkitie , A , Koskinen , S , Salomaa , V , Palotie , A , Ripatti , S & Palotie , T 2018 , ' Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland ' , BMJ Open , vol. 8 , no. 10 , 022752 . https://doi.org/10.1136/bmjopen-2018-022752 en
dc.identifier.issn 2044-6055
dc.identifier.other PURE: 121350012
dc.identifier.other PURE UUID: 05d57716-421e-40aa-b16b-aa0b7fd7f7ce
dc.identifier.other WOS: 000454739500114
dc.identifier.other Scopus: 85055072431
dc.identifier.other ORCID: /0000-0002-8306-6202/work/52863436
dc.identifier.other ORCID: /0000-0002-7367-6613/work/52867207
dc.identifier.other ORCID: /0000-0002-2527-5874/work/97266521
dc.identifier.uri http://hdl.handle.net/10138/298690
dc.description.abstract Objective To evaluate if obstructive sleep apnoea (OSA) modifies the risk of coronary heart disease, type 2 diabetes (T2D) and diabetic complications in a gender-specific fashion. Design and setting A longitudinal population-based study with up to 25-year follow-up data on 36 963 individuals (>500 000 person years) from three population-based cohorts: the FINRISK study, the Health 2000 Cohort Study and the Botnia Study. Main outcome measures Incident coronary heart disease, diabetic kidney disease, T2D and all-cause mortality from the Finnish National Hospital Discharge Register and the Finnish National Causes-of-Death Register. Results After adjustments for age, sex, region, high-density lipoprotein (HDL) and total cholesterol, current cigarette smoking, body mass index, hypertension, T2D baseline and family history of stroke or myocardial infarction, OSA increased the risk for coronary heart disease (HR=1.36, p=0.0014, 95% CI 1.12 to 1.64), particularly in women (HR=2.01, 95% CI 1.31 to 3.07, p=0.0012). T2D clustered with OSA independently of obesity (HR=1.48, 95% CI 1.26 to 1.73, p=9.11x10(-7)). The risk of diabetic kidney disease increased 1.75-fold in patients with OSA (95% CI 1.13 to 2.71, p=0.013). OSA increased the risk for coronary heart disease similarly among patients with T2D and in general population (HR=1.36). All-cause mortality was increased by OSA in diabetic individuals (HR=1.35, 95% CI 1.06 to 1.71, p=0.016). Conclusion OSA is an independent risk factor for coronary heart disease, T2D and diabetic kidney disease. This effect is more pronounced even in women, who until now have received less attention in diagnosis and treatment of OSA than men. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof BMJ Open
dc.rights en
dc.subject MIDDLE-AGED MEN en
dc.subject NEPHROPATHY en
dc.subject ASSOCIATION en
dc.subject PREVALENCE en
dc.subject 3121 General medicine, internal medicine and other clinical medicine en
dc.subject 3125 Otorhinolaryngology, ophthalmology en
dc.title Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes : a longitudinal population-based study in Finland en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1136/bmjopen-2018-022752
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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