Acute fulminant necrotizing myopathy in a dog caused by co-infection with ultrastructural Sarcocystis caninum and Sarcocystis svanai-like apicomplexan protozoa

Show simple item record

dc.contributor University of Helsinki, Medicum en
dc.contributor University of Helsinki, Antti Sukura / Principal Investigator en
dc.contributor.author Hagner, Karolina
dc.contributor.author Jokinen, Tarja S.
dc.contributor.author Lavikainen, Antti
dc.contributor.author Sukura, Antti
dc.date.accessioned 2019-02-05T22:38:25Z
dc.date.available 2021-10-15T21:47:17Z
dc.date.issued 2018-03-15
dc.identifier.citation Hagner , K , Jokinen , T S , Lavikainen , A & Sukura , A 2018 , ' Acute fulminant necrotizing myopathy in a dog caused by co-infection with ultrastructural Sarcocystis caninum and Sarcocystis svanai-like apicomplexan protozoa ' , Veterinary Parasitology , vol. 252 , pp. 153-156 . https://doi.org/10.1016/j.vetpar.2018.02.011 en
dc.identifier.issn 0304-4017
dc.identifier.other PURE: 98410020
dc.identifier.other PURE UUID: 61d913e4-73a8-46c0-9272-cbdbe833ea68
dc.identifier.other RIS: urn:4829DE1DF670DCE9F6C0F63BBE72AEBE
dc.identifier.other Scopus: 85042201006
dc.identifier.other WOS: 000430775000029
dc.identifier.other ORCID: /0000-0002-8992-1695/work/75942726
dc.identifier.uri http://hdl.handle.net/10138/298711
dc.description.abstract Abstract Typically, carnivores are the definitive and herbivores the intermediate hosts for protozoan Sarcocystis spp. In the definitive host, the parasite has sexual multiplication in the intestine. Asexual phases occur in the musculature of different intermediate hosts. Although intestinal sarcocystosis is common in dogs, muscular symptomatic sarcocystosis is rarely reported. Here we report a fatal dual Sarcocystis spp. infection in a dog. The dog had acute onset of non-ambulatory tetraparesis. While neurological findings suggested a generalized neuromuscular disease with peripheral neuropathy concordant with the neurological deficits, the highly elevated muscle enzymes were more suggestive of a myopathy. Despite supportive therapy, the dog died three days after the onset of clinical signs. Necropsy revealed severe monophasic multifocal myodegeneration with severe pyogranulomatous inflammation. Histology revealed multiple sarcocysts in skeletal muscles and a smaller number in the heart. In light microscopy, both thin-walled and very thin-walled sarcocysts were found in skeletal muscles. Transmission electron microscopy confirmed the presence of two types of mature sarcocysts. Morphologically, cysts were indistinguishable from Sarcocystis caninum and Sarcocystis svanai, which were previously reported in a dog from USA. A region of the 18S rRNA gene sequence confirmed the presence of one species, S. arctica/caninum, without evidence for a dual infection. This is the first report of muscular sarcocystosis in a dog in Europe and, intriguingly, revealed morphologically similar species across the Atlantic. en
dc.format.extent 4
dc.language.iso eng
dc.relation.ispartof Veterinary Parasitology
dc.rights en
dc.subject Sarcocystis spp en
dc.subject Canine en
dc.subject Muscular sarcocystosis en
dc.subject MUSCULAR SARCOCYSTOSIS en
dc.subject INTERMEDIATE HOST en
dc.subject SEVERE MYOSITIS en
dc.subject VULPES-LAGOPUS en
dc.subject 413 Veterinary science en
dc.title Acute fulminant necrotizing myopathy in a dog caused by co-infection with ultrastructural Sarcocystis caninum and Sarcocystis svanai-like apicomplexan protozoa en
dc.type Article
dc.description.version Peer reviewed
dc.date.embargoedUntil 2019-02-06
dc.identifier.doi https://doi.org/10.1016/j.vetpar.2018.02.011
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/acceptedVersion
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl
dc.contributor.pbl

Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0304401718300608_main.pdf 635.0Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record