Lymphatic Vascular Structures : A New Aspect in Proliferative Diabetic Retinopathy

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Gucciardo , E , Loukovaara , S , Salven , P & Lehti , K 2018 , ' Lymphatic Vascular Structures : A New Aspect in Proliferative Diabetic Retinopathy ' , International Journal of Molecular Sciences , vol. 19 , no. 12 , 4034 . https://doi.org/10.3390/ijms19124034

Title: Lymphatic Vascular Structures : A New Aspect in Proliferative Diabetic Retinopathy
Author: Gucciardo, Erika; Loukovaara, Sirpa; Salven, Petri; Lehti, Kaisa
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Department of Ophthalmology and Otorhinolaryngology
University of Helsinki, Department of Pathology
University of Helsinki, Kaisa Irene Lehti / Principal Investigator
Date: 2018-12
Language: eng
Number of pages: 25
Belongs to series: International Journal of Molecular Sciences
ISSN: 1422-0067
URI: http://hdl.handle.net/10138/298731
Abstract: Diabetic retinopathy (DR) is the most common diabetic microvascular complication and major cause of blindness in working-age adults. According to the level of microvascular degeneration and ischemic damage, DR is classified into non-proliferative DR (NPDR), and end-stage, proliferative DR (PDR). Despite advances in the disease etiology and pathogenesis, molecular understanding of end-stage PDR, characterized by ischemia- and inflammation-associated neovascularization and fibrosis, remains incomplete due to the limited availability of ideal clinical samples and experimental research models. Since a great portion of patients do not benefit from current treatments, improved therapies are essential. DR is known to be a complex and multifactorial disease featuring the interplay of microvascular, neurodegenerative, metabolic, genetic/epigenetic, immunological, and inflammation-related factors. Particularly, deeper knowledge on the mechanisms and pathophysiology of most advanced PDR is critical. Lymphatic-like vessel formation coupled with abnormal endothelial differentiation and progenitor cell involvement in the neovascularization associated with PDR are novel recent findings which hold potential for improved DR treatment. Understanding the underlying mechanisms of PDR pathogenesis is therefore crucial. To this goal, multidisciplinary approaches and new ex vivo models have been developed for a more comprehensive molecular, cellular and tissue-level understanding of the disease. This is the first step to gain the needed information on how PDR can be better evaluated, stratified, and treated.
Subject: angiogenesis
lymphatics
lymphangiogenesis
proliferative diabetic retinopathy
Lyve1
endothelial progenitor cell
ocular
ENDOTHELIAL GROWTH-FACTOR
OPTICAL COHERENCE TOMOGRAPHY
PROGENITOR-CELL ACTIVATION
CILIARY BODY
SUFFICIENT EVIDENCE
MACULAR EDEMA
VEGF-C
LYMPHANGIOGENESIS
VESSELS
EXPRESSION
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
3111 Biomedicine
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