Plant IsomiR Atlas

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http://hdl.handle.net/10138/298906

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Yang , K , Wen , X , Mudunuri , S B & Sablok , G 2019 , ' Plant IsomiR Atlas : Large Scale Detection, Profiling, and Target Repertoire of IsomiRs in Plants ' , Frontiers in plant science , vol. 9 , 1881 . https://doi.org/10.3389/fpls.2018.01881

Julkaisun nimi: Plant IsomiR Atlas;
Large Scale Detection, Profiling, and Target Repertoire of IsomiRs in Plants
Tekijä: Yang, Kun; Wen, Xiaopeng; Mudunuri, Suresh B.; Sablok, Gaurav
Muu tekijä: University of Helsinki, Plant Biology
Kuuluu julkaisusarjaan: Frontiers in plant science
ISSN: 1664-462X
Tiivistelmä: microRNAs (miRNAs) play an important role as key regulators controlling the post-transcriptional events in plants across development, abiotic and biotic stress, tissue polarity and also in defining the evolutionary basis of the origin of the post-transcriptional machinery. Identifying patterns of regulated and co-regulated small RNAs, in particular miRNAs and their sequence variants with the availability of next generation sequencing approaches has widely demonstrated the role of miRNAs and their temporal regulation in maintaining plant development and their response to stress conditions. Although the role of canonical miRNAs has been widely explored and functional diversity is revealed, those works for isomiRs are still limited and urgent to be carried out across plants. This relative lack of information with respect to isomiRs might be attributed to the non-availability of large-scale detection of isomiRs across wide plant species. In the present research, we addressed this by developing Plant isomiR Atlas, which provides large-scale detection of isomiRs across 23 plant species utilizing 677 smallRNAs datasets and reveals a total of 98,374 templated and non-templated isomiRs from 6,167 precursors. Plant isomiR Atlas provides several visualization features such as species specific isomiRs, isomiRs and canonical miRNAs overlap, terminal modification classifications, target identification using psRNATarget and TargetFinder and also canonical miRNAs: target interactions. Plant isomiR Atlas will play a key role in understanding the regulatory nature of miRNAome and will accelerate to understand the functional role of isomiRs. ONE SENTENCE SUMMARY Plant isomiR Atlas will play a key role in understanding the regulatory nature of miRNAome and will accelerate the understanding and diversity of functional targets of plants isomiRs.
URI: http://hdl.handle.net/10138/298906
Päiväys: 2019-01-22
Avainsanat: isomiRs
microRNAs
plants
post-transcriptional machinery
functional targets
EXPRESSION
TOLERANCE
MICRORNAS
REVEALS
EVENTS
MIRNA
1183 Plant biology, microbiology, virology
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