Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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http://hdl.handle.net/10138/298927

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UK10K Consortium 2019 , ' Low-frequency variation in TP53 has large effects on head circumference and intracranial volume ' , Nature Communications , vol. 10 , 357 . https://doi.org/10.1038/s41467-018-07863-x

Title: Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
Author: UK10K Consortium
Date: 2019-01-21
Language: eng
Number of pages: 16
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/298927
Abstract: Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determinants of ICV. Investigating up to 46,000 children and adults of European descent, we identify association with final HC and/or final ICV + HC at 9 novel common and low-frequency loci, illustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth. The largest effects are reported for low-frequency variants within TP53, with 0.5 cm wider heads in increaser-allele carriers versus non-carriers during mid-childhood, suggesting a previously unrecognized role of TP53 transcripts in human cranial development.
Subject: GENOME-WIDE ASSOCIATION
LD SCORE REGRESSION
GENETIC ARCHITECTURE
COMMON VARIANTS
GROWTH
BRAIN
GWAS
HERITABILITY
IMPUTATION
WEIGHT
3111 Biomedicine
1184 Genetics, developmental biology, physiology
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