Rationale and Plan for Vitamin D Food Fortification : A Review and Guidance Paper

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Pilz , S , Maerz , W , Cashman , K D , Kiely , M E , Whiting , S J , Holick , M F , Grant , W B , Pludowski , P , Hiligsmann , M , Trummer , C , Schwetz , V , Lerchbaum , E , Pandis , M , Tomaschitz , A , Gruebler , M R , Gaksch , M , Verheyen , N , Hollis , B W , Rejnmark , L , Karras , S N , Hahn , A , Bischoff-Ferrari , H A , Reichrath , J , Jorde , R , Elmadfa , I , Vieth , R , Scragg , R , Calvo , M S , van Schoor , N M , Bouillon , R , Lips , P , Itkonen , S T , Martineau , A R , Lamberg-Allardt , C & Zittermann , A 2018 , ' Rationale and Plan for Vitamin D Food Fortification : A Review and Guidance Paper ' , Frontiers in Endocrinology , vol. 9 , 373 . https://doi.org/10.3389/fendo.2018.00373

Title: Rationale and Plan for Vitamin D Food Fortification : A Review and Guidance Paper
Author: Pilz, Stefan; Maerz, Winfried; Cashman, Kevin D.; Kiely, Mairead E.; Whiting, Susan J.; Holick, Michael F.; Grant, William B.; Pludowski, Pawel; Hiligsmann, Mickael; Trummer, Christian; Schwetz, Verena; Lerchbaum, Elisabeth; Pandis, Marlene; Tomaschitz, Andreas; Gruebler, Martin R.; Gaksch, Martin; Verheyen, Nicolas; Hollis, Bruce W.; Rejnmark, Lars; Karras, Spyridon N.; Hahn, Andreas; Bischoff-Ferrari, Heike A.; Reichrath, Jörg; Jorde, Rolf; Elmadfa, Ibrahim; Vieth, Reinhold; Scragg, Robert; Calvo, Mona S.; van Schoor, Natasja M.; Bouillon, Roger; Lips, Paul; Itkonen, Suvi T.; Martineau, Adrian R.; Lamberg-Allardt, Christel; Zittermann, Armin
Contributor: University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
Date: 2018
Language: eng
Number of pages: 16
Belongs to series: Frontiers in Endocrinology
ISSN: 1664-2392
URI: http://hdl.handle.net/10138/298934
Abstract: Vitamin D deficiency can lead to musculoskeletal diseases such as rickets and osteomalacia, but vitamin D supplementation may also prevent extraskeletal diseases such as respiratory tract infections, asthma exacerbations, pregnancy complications and premature deaths. Vitamin D has a unique metabolism as it is mainly obtained through synthesis in the skin under the influence of sunlight (i.e., ultraviolet-B radiation) whereas intake by nutrition traditionally plays a relatively minor role. Dietary guidelines for vitamin D are based on a consensus that serum 25-hydroxyvitamin D (25[OH]D) concentrations are used to assess vitamin D status, with the recommended target concentrations ranging from >= 25 to >= 50 nmol/L (>= 10->= 20 ng/mL), corresponding to a daily vitamin D intake of 10 to 20 mu g (400-800 international units). Most populations fail to meet these recommended dietary vitamin D requirements. In Europe, 25(OH)D concentrations <30 nmol/L (12 ng/mL) and <50 nmol/L (20 ng/mL) are present in 13.0 and 40.4% of the general population, respectively. This substantial gap between officially recommended dietary reference intakes for vitamin D and the high prevalence of vitamin D deficiency in the general population requires action from health authorities. Promotion of a healthier lifestyle with more outdoor activities and optimal nutrition are definitely warranted but will not erase vitamin D deficiency and must, in the case of sunlight exposure, be well balanced with regard to potential adverse effects such as skin cancer. Intake of vitamin D supplements is limited by relatively poor adherence (in particular in individuals with low-socioeconomic status) and potential for overdosing. Systematic vitamin D food fortification is, however, an effective approach to improve vitamin D status in the general population, and this has already been introduced by countries such as the US, Canada, India, and Finland. Recent advances in our knowledge on the safety of vitamin D treatment, the dose-response relationship of vitamin D intake and 25(OH)D levels, as well as data on the effectiveness of vitamin D fortification in countries such as Finland provide a solid basis to introduce and modify vitamin D food fortification in order to improve public health with this likewise cost-effective approach.
Subject: vitamin D
public health
food forti fication
general population
guidelines
evidence
recommendations
policy
SERUM 25-HYDROXYVITAMIN D
PUBLIC-HEALTH IMPACT
RANDOMIZED CLINICAL-TRIAL
FORTIFIED DAIRY-PRODUCTS
D DEFICIENCY PREVENTION
YOUNG FINNISH MEN
D SUPPLEMENTATION
FRACTURE PREVENTION
OSTEOPOROTIC FRACTURES
CARDIOVASCULAR-DISEASE
3143 Nutrition
3121 General medicine, internal medicine and other clinical medicine
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