FOXP3(+) T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome

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Rytkönen , S H , Kulmala , P , Autio-Harmainen , H , Arikoski , P , Enden , K , Kataja , J , Karttunen , T , Nuutinen , M & Jahnukainen , T 2018 , ' FOXP3(+) T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome ' , Pediatric Nephrology , vol. 33 , no. 2 , pp. 287-293 . https://doi.org/10.1007/s00467-017-3796-z

Title: FOXP3(+) T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome
Author: Rytkönen, Sari H.; Kulmala, Petri; Autio-Harmainen, Helena; Arikoski, Pekka; Enden, Kira; Kataja, Janne; Karttunen, Tuomo; Nuutinen, Matti; Jahnukainen, Timo
Contributor: University of Helsinki, Children's Hospital
Date: 2018-02
Language: eng
Number of pages: 7
Belongs to series: Pediatric Nephrology
ISSN: 0931-041X
URI: http://hdl.handle.net/10138/298948
Abstract: Tubulointerstitial nephritis (TIN) is an inflammatory disease of unknown pathogenesis. To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and quantity of FOXP3(+) T regulatory lymphocytes in diagnostic kidney biopsies from pediatric patients. A total of 33 patients (14 TIN and 19 TINU) were enrolled. The quantity of CD4(+), FOXP3(+) and double-positive T cells in formalin-fixed kidney biopsies was determined using double label immunohistochemistry with anti-human CD4 and FOXP3 antibodies. FOXP3 staining was successful in all 33 patients. In patients with chronic uveitis, the density of FOXP3(+) cells was significantly lower (p = 0.046) than in TIN patients without uveitis or with uveitis lasting <3 months. CD4(+) staining was successful in 23 patients. The density of all lymphocytes (CD4(+), CD4(+)FOXP3(+) and FOXP3(+) cells) was significantly lower (p = 0.023) in patients with chronic uveitis than in other patients. FOXP3(+) T cells are present in kidney biopsy samples from TIN and TINU patients. In patients with chronic uveitis, the density of FOXP3(+) T cells is significantly lower than in other patients, suggesting a different pathomechanism for these clinical conditions.
Subject: Tubulointerstitial nephritis
Regulatory T cell
Child
Biopsy
Uveitis
FOXP3
ACUTE INTERSTITIAL NEPHRITIS
WEGENERS-GRANULOMATOSIS
HLA ASSOCIATIONS
GLOMERULONEPHRITIS
INVOLVEMENT
SUPPRESSION
POPULATION
REJECTION
DISEASES
ALLELES
3123 Gynaecology and paediatrics
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