Progress in human picornavirus research : New findings from the AIROPico consortium

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Wolthers , K C , Susi , P , Jochmans , D , Koskinen , J , Landt , O , Sanchez , N , Palm , K , Neyts , J & Butcher , S J 2019 , ' Progress in human picornavirus research : New findings from the AIROPico consortium ' , Antiviral Research , vol. 161 , pp. 100-107 . https://doi.org/10.1016/j.antiviral.2018.11.010

Title: Progress in human picornavirus research : New findings from the AIROPico consortium
Author: Wolthers, Katja C.; Susi, Petri; Jochmans, Dirk; Koskinen, Janne; Landt, Olfert; Sanchez, Neus; Palm, Kaia; Neyts, Johan; Butcher, Sarah J.
Contributor: University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2019-01
Language: eng
Number of pages: 8
Belongs to series: Antiviral Research
ISSN: 0166-3542
URI: http://hdl.handle.net/10138/299003
Abstract: Several research groups in Europe are active on different aspects of human picornavirus research. The AIROPico (Academia-Industry R&D Opportunities for Picornaviruses) consortium combined the disciplines of pathogenesis, diagnostics and therapy development in order to fill the gaps in our understanding of how picornaviruses cause human disease and how to combat them. AIROPico was the first EU consortium dedicated to human picornavirus research and development, and has largely accelerated and improved R&D on picornavirus biology, diagnostics and therapy. In this article, we present the progress on pathogenesis, diagnostics and treatment strategy developments for human picornaviruses resulting from the structured, translational research approach of the AIROPico consortium. We here summarize new insights in protection against infection by maternal or cross-protective antibodies, the visualisation of interactions between virus and neutralizing antibodies by cryoEM structural imaging, and the outcomes from a picornavirus-infected human 3D organoid. Progress in molecular detection and a fast typing assay for rhinovirus species are presented, as well as the identification of new compounds potentially interesting as therapeutic compounds.
Subject: Picomavirus
Enterovirus
Point of care (POC) diagnostics
Pathogenesis
Antiviral therapy
RESPIRATORY VIRAL-INFECTIONS
DISEASE
NEUTRALIZATION
REPLICATION
ASSOCIATION
PERFORMANCE
INHIBITORS
INFLUENZA
OUTBREAK
VIRUSES
1183 Plant biology, microbiology, virology
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