Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women

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http://hdl.handle.net/10138/299127

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Liuhanen , J , Suvisaari , J , Kajantie , E , Miettunen , J , Sarin , A-P , Järvelin , M-R , Lönnqvist , J , Veijola , J & Paunio , T 2018 , ' Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women ' , Psychiatry Research , vol. 259 , pp. 148-153 . https://doi.org/10.1016/j.psychres.2017.10.020

Title: Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women
Author: Liuhanen, Johanna; Suvisaari, Jaana; Kajantie, Eero; Miettunen, Jouko; Sarin, Antti-Pekka; Järvelin, Marjo-Riitta; Lönnqvist, Jouko; Veijola, Juha; Paunio, Tiina
Contributor: University of Helsinki, Lastentautien yksikkö
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2018-01
Language: eng
Number of pages: 6
Belongs to series: Psychiatry Research
ISSN: 0165-1781
URI: http://hdl.handle.net/10138/299127
Abstract: Schizophrenia is a highly heritable disease, but despite extensive study, its genetic background remains unresolved. The lack of environmental measures in genetic studies may offer some explanation. In recent Finnish studies, high birth weight was found to increase the risk for familial schizophrenia. We examined the interaction between a polygenic risk score for schizophrenia and high birth weight on social anhedonia and schizophrenia in a general population birth cohort. The study sample included 4223 participants from the 1966 Northern Finland Birth Cohort. As a replication sample we used 256 participants from a systematically collected sample of Finnish schizophrenia families. The polygenic risk score comprised of variants published in the large genome-wide meta analysis for schizophrenia. We found the association between the polygenic risk score and social anhedonia stronger among those with high birth weight, and the same phenomenon was seen for schizophrenia among women, suggesting a gene-environment interaction. Similar results were found within the replication sample. Our results suggest a role for gene-environment interactions in assessing the risk of schizophrenia. Failure to take environmental effects into account may be one of the reasons why identifying significant SNPs for schizophrenia in genome-wide studies has been challenging.
Subject: Gene-environment interaction
Schizophrenia
GENOME-WIDE ASSOCIATION
PSYCHIATRIC-DISORDERS
SPECTRUM DISORDERS
SEX-DIFFERENCES
COHORT
POPULATION
SCALES
METAANALYSIS
HISTORY
FAMILY
3124 Neurology and psychiatry
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