Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers

Show full item record



Permalink

http://hdl.handle.net/10138/299132

Citation

Lehikoinen , A I , Kärkkäinen , O K , Lehtonen , M A S , Auriola , S O K , Hanhineva , K J & Heinonen , S T 2018 , ' Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers ' , European Journal of Obstetrics, and Gynecology ,and Reproductive Biology , vol. 223 , pp. 79-84 . https://doi.org/10.1016/j.ejogrb.2018.02.004

Title: Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Author: Lehikoinen, Anni I.; Kärkkäinen, Olli K.; Lehtonen, Marko A.S.; Auriola, Seppo O.K.; Hanhineva, Kati J.; Heinonen, Seppo T.
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
Date: 2018-04
Language: eng
Number of pages: 6
Belongs to series: European Journal of Obstetrics, and Gynecology ,and Reproductive Biology
ISSN: 0301-2115
URI: http://hdl.handle.net/10138/299132
Abstract: Background: Although the effects of alcohol on metabolic processes in the body have been studied widely, there do not appear to be any previous reports clarifying how substance abuse changes metabolic profiles of pregnant women during the first trimester of pregnancy. Objective: Our aim was to evaluate the effect of substance abuse, especially alcohol use, on the metabolic profile of pregnant women during the first trimester. Study design: We applied mass spectrometry based non-targeted metabolite profiling of serum collected during routine visit to the hospital between gestational weeks 9 + 0 to 11 + 6 from controls (n = 55), alcohol users (n = 19), drug users (n = 24) and tobacco smokers (n = 40). Results: We observed statistically significantly differences among the study groups in serum levels of glutamate, glutamine, and serotonin (p-values Conclusion: The present study shows that alcohol and drug use were associated with increased glutamate, and decreased glutamine levels, and alcohol use is associated with decreased serotonin levels. This study serves as a proof-of-concept that the metabolite profile of human first trimester serum samples could be used to detect alcohol exposure during pregnancy. (C) 2018 Elsevier B.V. All rights reserved.
Subject: 3123 Gynaecology and paediatrics
Alcohol
Metabolomics
Metabolism
Pregnancy
Prenatal diagnosis
Smoking
BIOCHEMICAL MARKERS
ADDICTION
DEPENDENCE
RESONANCE-SPECTROSCOPY
CENTRAL GLUTAMATE
ETHANOL
USE DISORDERS
CONSUMPTION
BRAIN
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
1_s2.0_S0301211518300605_main.pdf 615.9Kb PDF View/Open
1_s2.0_S0301211518300605_main_1.pdf 697.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record