Increased risk for stress urinary incontinence in women with postmenopausal hormone therapy

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dc.contributor University of Helsinki, HUS Gynecology and Obstetrics en
dc.contributor University of Helsinki, Department of Obstetrics and Gynecology en
dc.contributor University of Helsinki, HUS Gynecology and Obstetrics en
dc.contributor University of Helsinki, HUS Gynecology and Obstetrics en
dc.contributor.author Rahkola-Soisalo, Päivi
dc.contributor.author Savolainen-Peltonen, Hanna
dc.contributor.author Mika, Gissler
dc.contributor.author Hoti, Fabian
dc.contributor.author Vattulainen, Pia
dc.contributor.author Ylikorkala, Olavi
dc.contributor.author Mikkola, Tomi S.
dc.date.accessioned 2019-02-18T08:53:01Z
dc.date.available 2019-02-18T08:53:01Z
dc.date.issued 2019-02
dc.identifier.citation Rahkola-Soisalo , P , Savolainen-Peltonen , H , Mika , G , Hoti , F , Vattulainen , P , Ylikorkala , O & Mikkola , T S 2019 , ' Increased risk for stress urinary incontinence in women with postmenopausal hormone therapy ' , International Urogynecology Journal , vol. 30 , no. 2 , pp. 251-256 . https://doi.org/10.1007/s00192-018-3682-7 en
dc.identifier.issn 0937-3462
dc.identifier.other PURE: 122135692
dc.identifier.other PURE UUID: 4f3ff81a-b487-4fb8-b558-50852b4dd7f8
dc.identifier.other Scopus: 85049065589
dc.identifier.other ORCID: /0000-0003-2049-088X/work/54487871
dc.identifier.other ORCID: /0000-0001-7512-4823/work/54488227
dc.identifier.other ORCID: /0000-0003-4139-669X/work/54489802
dc.identifier.other WOS: 000457986300012
dc.identifier.uri http://hdl.handle.net/10138/299149
dc.description.abstract Introduction and hypothesisThe impact of estradiol-based hormone therapy (HT) on the incidence of stress urinary incontinence (SUI) is unknown. Therefore, we compared the use of such HT regimens and tibolone in women with and without SUI.MethodsThe women with a history of SUI operation (N=15,002) were identified from the Finnish National Hospital Discharge Register, and the control women without such an operation (N=44,389) from the Finnish Central Population Register. The use of HT was traced from the National Drug Reimbursement Register, and the odd ratios (ORs) with 95% confidence intervals (95% CIs) for SUI were calculated by using the conditional logistic regression analysis.ResultsThe cases had used any HT more often than the controls. The use of systemic estradiol-only or estradiol-progestin therapy was accompanied by an increased SUI risk (OR 3.8, 95% CI: 3.6-4.0 and OR 2.7, 95% CI: 2.6-2.9 respectively). The use of estradiol with noretisterone acetate showed a higher risk of increase than that with medroxyprogesterone acetate. Age over 55years at the initiation of systemic HT was accompanied by a higher SUI risk increase than that under 55years of age. The use of tibolone, an estradiol + levonorgestrel-releasing intrauterine device, or vaginal estradiol also increased the risk.ConclusionsThe use of HT regimens may predispose to the de novo development or worsening of pre-existing SUI. Thus, caution is needed when these regimens are prescribed to women with mild stress-related urine leakage or with established SUI risk factors. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof International Urogynecology Journal
dc.relation.uri https://rdcu.be/bnil6
dc.rights en
dc.subject 3123 Gynaecology and paediatrics en
dc.subject Estradiol en
dc.subject Hormone therapy en
dc.subject Menopause en
dc.subject Stress urinary incontinence en
dc.subject FREE VAGINAL TAPE en
dc.subject ESTROGEN en
dc.subject MENOPAUSE en
dc.subject ESTRADIOL en
dc.title Increased risk for stress urinary incontinence in women with postmenopausal hormone therapy en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1007/s00192-018-3682-7
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
dc.contributor.pbl
dc.contributor.pbl

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