Etiological diagnosis of childhood pneumonia by use of transthoracic needle aspiration and modern microbiological methods

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Vuori-Holopainen , E , Salo , E , Saxen , H , Hedman , K , Hyypiä , T , Lahdenperä , R , Leinonen , M , Tarkka , E , Vaara , M & Peltola , H 2002 , ' Etiological diagnosis of childhood pneumonia by use of transthoracic needle aspiration and modern microbiological methods ' , Clinical Infectious Diseases , vol. 34 , no. 5 , pp. 583-590 . https://doi.org/10.1086/338642

Title: Etiological diagnosis of childhood pneumonia by use of transthoracic needle aspiration and modern microbiological methods
Author: Vuori-Holopainen, Elina; Salo, Eeva; Saxen, Harri; Hedman, Klaus; Hyypiä, Timo; Lahdenperä, Raija; Leinonen, Maija; Tarkka, Eveliina; Vaara, Martti; Peltola, Heikki
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
University of Helsinki, Klaus Hedman / Principal Investigator
University of Helsinki, Department of Virology
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Department of Bacteriology and Immunology
University of Helsinki, Children's Hospital
Date: 2002-03-01
Language: eng
Number of pages: 8
Belongs to series: Clinical Infectious Diseases
ISSN: 1058-4838
URI: http://hdl.handle.net/10138/299235
Abstract: Childhood pneumonia is usually treated without determining its etiology. The causative organism can be isolated from specimens of blood, empyema fluid, or lung aspirate, but this is rarely done. The potential of transthoracic needle aspiration for identification of causative agents was tested with use of modern microbiological methods. Aspiration was performed for 34 children who had radiological signs compatible with community-acquired pneumonia and had alveolar consolidation. In addition to bacterial and viral cultures and viral antigen detection, nucleic acid detection for common respiratory pathogens was performed on aspirate specimens. Aspiration disclosed the etiology in 20 (59%) of 34 cases overall and in 18 (69%) of 26 patients from whom a representative specimen was obtained. Aspiration's advantages are high microbiological yield and a relatively low risk of a clinically significant adverse event. Aspiration should be used if identification of the causative agent outweighs the modest risk of the procedure.
Subject: POLYMERASE CHAIN-REACTION
HAEMOPHILUS-INFLUENZAE
PNEUMOCOCCAL PNEUMONIA
CHILDREN
AMPLIFICATION
INFECTIONS
RELEVANCE
BACTERIAL
LUNG
DNA
3111 Biomedicine
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